Levels of cytokines and C-reactive protein as treatment effectiveness criteria in patients with coronary heart disease and chronic heart failure

• Main Authors: E. Yu. Sazhina, I. V. Kozlova
• Format: Article
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 2008-06-01
• Series: Кардиоваскулярная терапия и профилактика
• Subjects: chronic heart failure; ace inhibitors; aspirin; cytokines
• Online Access: https://cardiovascular.elpub.ru/jour/article/view/1385

Aim. To study clinical and diagnostic value of chronic inflammation markers in patients with chronic heart failure (CHF), receiving standard therapy (ST) including ACE inhibitors, or ST including ACE I inhibitors combined with aspirin (ST + aspirin).Material and methods. The study included 120 CHF patients aged 45-74 years. Clinical examination and measurement of serum cytokine levels (solid-phase immuno-enzyme analysis) and plasma C-reactive protein (CRP) level (photometric turbidimetry method) were performed.Results. In Functional Class (FC) II-III CHF patients, ST was associated with clinical improvement and decreased levels of pro-inflammatory cytokines and CRP. ST + aspirin therapy was not associated with the decrease in cytokine and CRP levels; moreover, these levels were increased in some FC II-III CHF individuals.Conclusion. The results obtained could be used as additional criteria for CHF clinical course assessment and therapy effectiveness control.