An emerging public health threat: Mayaro virus increases its distribution in Peru
Background: The infection caused by Mayaro virus (MAYV), which presents as an acute febrile illness, is considered a neglected tropical disease. The virus is an endemic and emerging pathogen in South America and the Caribbean, responsible for occasional and poorly characterized outbreaks. Currently...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-03-01
|
Series: | International Journal of Infectious Diseases |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220300266 |
id |
doaj-2975e5a5acf24f009759ca2f8a6367df |
---|---|
record_format |
Article |
spelling |
doaj-2975e5a5acf24f009759ca2f8a6367df2020-11-25T02:04:41ZengElsevierInternational Journal of Infectious Diseases1201-97122020-03-0192253258An emerging public health threat: Mayaro virus increases its distribution in PeruMiguel Angel Aguilar-Luis0Juana del Valle-Mendoza1Wilmer Silva-Caso2Tamara Gil-Ramirez3Saul Levy-Blitchtein4Jorge Bazán-Mayra5Victor Zavaleta-Gavidia6Daniel Cornejo-Pacherres7Carlos Palomares-Reyes8Luis J. del Valle9School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Laboratorio de Biología Molecular, Instituto de Investigación Nutricional, Lima, PeruSchool of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Laboratorio de Biología Molecular, Instituto de Investigación Nutricional, Lima, Peru; Corresponding author at: Universidad Peruana de Ciencias Aplicadas, Av. San Marcos cuadra 2, Chorrillos, Lima, Peru.School of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru; Laboratorio de Biología Molecular, Instituto de Investigación Nutricional, Lima, PeruSchool of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, PeruSchool of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, PeruLaboratorio de Referencia, Dirección Regional de Salud de Cajamarca (DIRESA), Cajamarca, PeruLaboratorio de Referencia, Dirección Regional de Salud de Cajamarca (DIRESA), Cajamarca, PeruLaboratorio de Referencia, Dirección Regional de Salud de Cajamarca (DIRESA), Cajamarca, PeruSchool of Medicine, Research and Innovation Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, PeruBarcelona Research Center for Multiscale Science and Engineering, Departament d’Enginyeria Química, EEBE, Universitat Politècnica de Catalunya, Barcelona, Spain; Corresponding author at: Universidad Politècnica de Catalunya (UPC), Barcelona Tech, Barcelona, Spain.Background: The infection caused by Mayaro virus (MAYV), which presents as an acute febrile illness, is considered a neglected tropical disease. The virus is an endemic and emerging pathogen in South America and the Caribbean, responsible for occasional and poorly characterized outbreaks. Currently there is limited information about its expansion and risk areas. Methods: A cross-sectional study was performed in 10 urban primary care health centers in the Cajamarca region of Peru from January to June 2017. A total of 359 patients with suspected febrile illness were assessed. RNA was extracted from serum samples, following which MAYV real-time reverse transcriptase PCR (RT-PCR) for the detection of the nsP1 gene was performed. Results: MAYV was detected in 11.1% (40/359) of samples after RT-PCR amplification and confirmatory DNA sequencing. Most infections were detected in the adult population aged 18–39 years (40%) and 40–59 years (32.5%). Headache was the most frequent symptom in patients with MAYV infection (77.5%), followed by fever (72.5%), myalgia (55.0%), and arthralgia (50.0%). During the study, most of the MAYV cases were seen in May (47.5%) and April (35.0%), corresponding to the dry season (months without rain). Conclusions: This study is novel in describing the presence of MAYV in Cajamarca, an Andean region of Peru. Symptoms are non-specific and can be confused with those of other arbovirus or bacterial infections. Molecular biology methods such as RT-PCR allow the timely and accurate detection of MAYV and could thus be considered as a tool for surveillance in endemic areas. Keywords: Mayaro virus, MAYV, RT-PCR, Togaviridae, Jungle feverhttp://www.sciencedirect.com/science/article/pii/S1201971220300266 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Miguel Angel Aguilar-Luis Juana del Valle-Mendoza Wilmer Silva-Caso Tamara Gil-Ramirez Saul Levy-Blitchtein Jorge Bazán-Mayra Victor Zavaleta-Gavidia Daniel Cornejo-Pacherres Carlos Palomares-Reyes Luis J. del Valle |
spellingShingle |
Miguel Angel Aguilar-Luis Juana del Valle-Mendoza Wilmer Silva-Caso Tamara Gil-Ramirez Saul Levy-Blitchtein Jorge Bazán-Mayra Victor Zavaleta-Gavidia Daniel Cornejo-Pacherres Carlos Palomares-Reyes Luis J. del Valle An emerging public health threat: Mayaro virus increases its distribution in Peru International Journal of Infectious Diseases |
author_facet |
Miguel Angel Aguilar-Luis Juana del Valle-Mendoza Wilmer Silva-Caso Tamara Gil-Ramirez Saul Levy-Blitchtein Jorge Bazán-Mayra Victor Zavaleta-Gavidia Daniel Cornejo-Pacherres Carlos Palomares-Reyes Luis J. del Valle |
author_sort |
Miguel Angel Aguilar-Luis |
title |
An emerging public health threat: Mayaro virus increases its distribution in Peru |
title_short |
An emerging public health threat: Mayaro virus increases its distribution in Peru |
title_full |
An emerging public health threat: Mayaro virus increases its distribution in Peru |
title_fullStr |
An emerging public health threat: Mayaro virus increases its distribution in Peru |
title_full_unstemmed |
An emerging public health threat: Mayaro virus increases its distribution in Peru |
title_sort |
emerging public health threat: mayaro virus increases its distribution in peru |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2020-03-01 |
description |
Background: The infection caused by Mayaro virus (MAYV), which presents as an acute febrile illness, is considered a neglected tropical disease. The virus is an endemic and emerging pathogen in South America and the Caribbean, responsible for occasional and poorly characterized outbreaks. Currently there is limited information about its expansion and risk areas. Methods: A cross-sectional study was performed in 10 urban primary care health centers in the Cajamarca region of Peru from January to June 2017. A total of 359 patients with suspected febrile illness were assessed. RNA was extracted from serum samples, following which MAYV real-time reverse transcriptase PCR (RT-PCR) for the detection of the nsP1 gene was performed. Results: MAYV was detected in 11.1% (40/359) of samples after RT-PCR amplification and confirmatory DNA sequencing. Most infections were detected in the adult population aged 18–39 years (40%) and 40–59 years (32.5%). Headache was the most frequent symptom in patients with MAYV infection (77.5%), followed by fever (72.5%), myalgia (55.0%), and arthralgia (50.0%). During the study, most of the MAYV cases were seen in May (47.5%) and April (35.0%), corresponding to the dry season (months without rain). Conclusions: This study is novel in describing the presence of MAYV in Cajamarca, an Andean region of Peru. Symptoms are non-specific and can be confused with those of other arbovirus or bacterial infections. Molecular biology methods such as RT-PCR allow the timely and accurate detection of MAYV and could thus be considered as a tool for surveillance in endemic areas. Keywords: Mayaro virus, MAYV, RT-PCR, Togaviridae, Jungle fever |
url |
http://www.sciencedirect.com/science/article/pii/S1201971220300266 |
work_keys_str_mv |
AT miguelangelaguilarluis anemergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT juanadelvallemendoza anemergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT wilmersilvacaso anemergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT tamaragilramirez anemergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT saullevyblitchtein anemergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT jorgebazanmayra anemergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT victorzavaletagavidia anemergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT danielcornejopacherres anemergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT carlospalomaresreyes anemergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT luisjdelvalle anemergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT miguelangelaguilarluis emergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT juanadelvallemendoza emergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT wilmersilvacaso emergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT tamaragilramirez emergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT saullevyblitchtein emergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT jorgebazanmayra emergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT victorzavaletagavidia emergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT danielcornejopacherres emergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT carlospalomaresreyes emergingpublichealththreatmayarovirusincreasesitsdistributioninperu AT luisjdelvalle emergingpublichealththreatmayarovirusincreasesitsdistributioninperu |
_version_ |
1724941785692635136 |