Overview of 99mTc-anti-TNF-α scintigraphy: diagnostic applications
Umut Elboga,1 Ebuzer Kalender,2 Hulya Yalcin21Department of Nuclear Medicine, Gaziantep University, Gaziantep, Turkey; 2Department of Nuclear Medicine, Mustafa Kemal University, Antioch, TurkeyAbstract: Tumor necrosis factor alpha (TNF-α) has a role in the pathogenesis of several inflamma...
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doaj-297d2a05f2c549dca00f9efb52738a922020-11-25T02:27:03ZengDove Medical PressReports in Medical Imaging1179-15862013-12-012014default1415325Overview of 99mTc-anti-TNF-α scintigraphy: diagnostic applicationsElboga UKalender EYalcin H Umut Elboga,1 Ebuzer Kalender,2 Hulya Yalcin21Department of Nuclear Medicine, Gaziantep University, Gaziantep, Turkey; 2Department of Nuclear Medicine, Mustafa Kemal University, Antioch, TurkeyAbstract: Tumor necrosis factor alpha (TNF-α) has a role in the pathogenesis of several inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. As TNF-α plays a role in the pathogenesis of different inflammatory diseases, anti-TNF-α agents (monoclonal antibodies [mAbs]) such as infliximab, adalimumab, and certolizumab have been developed and investigated for the treatment of these conditions. In recent years, these mAbs also have been used for diagnosis, monitoring, follow-up of disease activity, and therapy decision-making for inflammatory diseases, especially rheumatoid arthritis, after labeling with 99mTc. However, 99mTc-anti-TNF-α imaging might have severe adverse effects and is expensive. In contrast, scintigraphic imaging before therapy with radiolabeled mAbs may be a cost-effective solution for therapy decisions.Keywords: monoclonal antibodies, mAb, nuclear medicine, 99mTc tumor necrosis factor-α imaginghttp://www.dovepress.com/overview-of-99mtc-anti-tnf-alpha-scintigraphy-diagnostic-applications-a15325 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elboga U Kalender E Yalcin H |
spellingShingle |
Elboga U Kalender E Yalcin H Overview of 99mTc-anti-TNF-α scintigraphy: diagnostic applications Reports in Medical Imaging |
author_facet |
Elboga U Kalender E Yalcin H |
author_sort |
Elboga U |
title |
Overview of 99mTc-anti-TNF-α scintigraphy: diagnostic applications |
title_short |
Overview of 99mTc-anti-TNF-α scintigraphy: diagnostic applications |
title_full |
Overview of 99mTc-anti-TNF-α scintigraphy: diagnostic applications |
title_fullStr |
Overview of 99mTc-anti-TNF-α scintigraphy: diagnostic applications |
title_full_unstemmed |
Overview of 99mTc-anti-TNF-α scintigraphy: diagnostic applications |
title_sort |
overview of 99mtc-anti-tnf-α scintigraphy: diagnostic applications |
publisher |
Dove Medical Press |
series |
Reports in Medical Imaging |
issn |
1179-1586 |
publishDate |
2013-12-01 |
description |
Umut Elboga,1 Ebuzer Kalender,2 Hulya Yalcin21Department of Nuclear Medicine, Gaziantep University, Gaziantep, Turkey; 2Department of Nuclear Medicine, Mustafa Kemal University, Antioch, TurkeyAbstract: Tumor necrosis factor alpha (TNF-α) has a role in the pathogenesis of several inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis. As TNF-α plays a role in the pathogenesis of different inflammatory diseases, anti-TNF-α agents (monoclonal antibodies [mAbs]) such as infliximab, adalimumab, and certolizumab have been developed and investigated for the treatment of these conditions. In recent years, these mAbs also have been used for diagnosis, monitoring, follow-up of disease activity, and therapy decision-making for inflammatory diseases, especially rheumatoid arthritis, after labeling with 99mTc. However, 99mTc-anti-TNF-α imaging might have severe adverse effects and is expensive. In contrast, scintigraphic imaging before therapy with radiolabeled mAbs may be a cost-effective solution for therapy decisions.Keywords: monoclonal antibodies, mAb, nuclear medicine, 99mTc tumor necrosis factor-α imaging |
url |
http://www.dovepress.com/overview-of-99mtc-anti-tnf-alpha-scintigraphy-diagnostic-applications-a15325 |
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