Amino Acid Derivatives of Ligustrazine-Oleanolic Acid as New Cytotoxic Agents

A series of novel ligustrazine-oleanolic acid (TOA) derivatives were designed, and synthesized by conjugating amino acids to the 3-hydroxy group of TOA by ester bonds. Their cytotoxicity was evaluated on four cancer cell lines (HepG2, HT-29, Hela and BGC-823) by standard MTT assays. The ClogP value...

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Bibliographic Details
Main Authors: Fuhao Chu, Xin Xu, Guoliang Li, Shun Gu, Kuo Xu, Yan Gong, Bing Xu, Mina Wang, Huazheng Zhang, Yuzhong Zhang, Penglong Wang, Haimin Lei
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
Online Access:http://www.mdpi.com/1420-3049/19/11/18215