Review of spectral domain-enhanced depth imaging optical coherence tomography of tumors of the retina and retinal pigment epithelium in children and adults
Background: Spectral domain (SD) enhanced depth imaging optical coherence tomography (EDI-OCT) is a useful tool for anatomic, cross-sectional imaging of retinal conditions. Aims: The aim was to identify characteristic patterns of retinal and retinal pigment epithelial tumors on EDI-OCT in children a...
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doaj-2990000bcae8452cb03e8b52f6f4173e2020-11-25T00:44:24ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892015-01-0163212813210.4103/0301-4738.154384Review of spectral domain-enhanced depth imaging optical coherence tomography of tumors of the retina and retinal pigment epithelium in children and adultsCarol L ShieldsJanet ManalacChandana DasJarin SaktanasateJerry A ShieldsBackground: Spectral domain (SD) enhanced depth imaging optical coherence tomography (EDI-OCT) is a useful tool for anatomic, cross-sectional imaging of retinal conditions. Aims: The aim was to identify characteristic patterns of retinal and retinal pigment epithelial tumors on EDI-OCT in children and adults. Settings and Design: Retrospective review. Materials and Methods: Analysis of published reports and personal observations using office-based EDI-OCT for adults and portable hand-held SD OCT for infants and children. Results: Using EDI-OCT, retinal tumors such as small retinoblastoma, astrocytic hamartoma, and hemangioblastoma arose abruptly from the retina, immediately adjacent to normal retina. Small exophytic retinoblastoma and retinal hemangioblastoma showed the full-thickness, homogeneous retinal disorganization with surrounding normal retina "draping" over the margins. Retinoblastoma occasionally had intralesional cavities and surrounding subretinal fluid. Hemangioblastoma often had adjacent intraretinal edema and subretinal fluid. Astrocytic hamartoma arose within the nerve fiber layer and sometimes with a "moth-eaten" or cavitary appearance. Retinal pigment epithelial (RPE) lesions such as congenital hypertrophy of RPE appeared flat with shadowing, occasional subretinal cleft, and abrupt photoreceptor loss. Congenital simple hamartoma showed an abrupt elevation from the inner retina with crisp, dark posterior shadowing. Combined hamartoma of the retina/RPE showed vitreoretinal traction causing "sawtooth mini-peak" or gently "maxi-peak" folding of the retina. RPE adenoma often produces remote macular edema or epiretinal membrane and the tumor has an irregular, "rugged" surface with deep shadowing. Conclusions: Enhanced depth imaging optical coherence tomography shows characteristic patterns that are suggestive of certain retinal and RPE tumors.http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=2;spage=128;epage=132;aulast=ShieldsCiliary bodychoroideyeirismelanomametastasisprognosistumoruveaChemotherapyintravitreal chemotherapyintra-arterial chemotherapyintravenous chemotherapyperiocular chemotherapyretinoblastomaSubtenon′s chemotherapytreatmentAutoflouroscenceenhanced depth imagingeyegene expression profilingmalignancymetastasismonosomy 3nevusoptical coherence tomographytumoruveal melanomaChoroidenhanced depth imaging optical coherence tomographyhemangiomalymphomamelanocytosismelanomametastasisnevusosteomatumorChoroidEyemetastasesmetastasistumoruveaAstrocytic hamartomaenhanced depth imaging optical coherence tomographyhemangioblastomaretinaretinoblastomatumor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carol L Shields Janet Manalac Chandana Das Jarin Saktanasate Jerry A Shields |
spellingShingle |
Carol L Shields Janet Manalac Chandana Das Jarin Saktanasate Jerry A Shields Review of spectral domain-enhanced depth imaging optical coherence tomography of tumors of the retina and retinal pigment epithelium in children and adults Indian Journal of Ophthalmology Ciliary body choroid eye iris melanoma metastasis prognosis tumor uvea Chemotherapy intravitreal chemotherapy intra-arterial chemotherapy intravenous chemotherapy periocular chemotherapy retinoblastoma Subtenon′s chemotherapy treatment Autoflouroscence enhanced depth imaging eye gene expression profiling malignancy metastasis monosomy 3 nevus optical coherence tomography tumor uveal melanoma Choroid enhanced depth imaging optical coherence tomography hemangioma lymphoma melanocytosis melanoma metastasis nevus osteoma tumor Choroid Eye metastases metastasis tumor uvea Astrocytic hamartoma enhanced depth imaging optical coherence tomography hemangioblastoma retina retinoblastoma tumor |
author_facet |
Carol L Shields Janet Manalac Chandana Das Jarin Saktanasate Jerry A Shields |
author_sort |
Carol L Shields |
title |
Review of spectral domain-enhanced depth imaging optical coherence tomography of tumors of the retina and retinal pigment epithelium in children and adults |
title_short |
Review of spectral domain-enhanced depth imaging optical coherence tomography of tumors of the retina and retinal pigment epithelium in children and adults |
title_full |
Review of spectral domain-enhanced depth imaging optical coherence tomography of tumors of the retina and retinal pigment epithelium in children and adults |
title_fullStr |
Review of spectral domain-enhanced depth imaging optical coherence tomography of tumors of the retina and retinal pigment epithelium in children and adults |
title_full_unstemmed |
Review of spectral domain-enhanced depth imaging optical coherence tomography of tumors of the retina and retinal pigment epithelium in children and adults |
title_sort |
review of spectral domain-enhanced depth imaging optical coherence tomography of tumors of the retina and retinal pigment epithelium in children and adults |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Ophthalmology |
issn |
0301-4738 1998-3689 |
publishDate |
2015-01-01 |
description |
Background: Spectral domain (SD) enhanced depth imaging optical coherence tomography (EDI-OCT) is a useful tool for anatomic, cross-sectional imaging of retinal conditions. Aims: The aim was to identify characteristic patterns of retinal and retinal pigment epithelial tumors on EDI-OCT in children and adults. Settings and Design: Retrospective review. Materials and Methods: Analysis of published reports and personal observations using office-based EDI-OCT for adults and portable hand-held SD OCT for infants and children. Results: Using EDI-OCT, retinal tumors such as small retinoblastoma, astrocytic hamartoma, and hemangioblastoma arose abruptly from the retina, immediately adjacent to normal retina. Small exophytic retinoblastoma and retinal hemangioblastoma showed the full-thickness, homogeneous retinal disorganization with surrounding normal retina "draping" over the margins. Retinoblastoma occasionally had intralesional cavities and surrounding subretinal fluid. Hemangioblastoma often had adjacent intraretinal edema and subretinal fluid. Astrocytic hamartoma arose within the nerve fiber layer and sometimes with a "moth-eaten" or cavitary appearance. Retinal pigment epithelial (RPE) lesions such as congenital hypertrophy of RPE appeared flat with shadowing, occasional subretinal cleft, and abrupt photoreceptor loss. Congenital simple hamartoma showed an abrupt elevation from the inner retina with crisp, dark posterior shadowing. Combined hamartoma of the retina/RPE showed vitreoretinal traction causing "sawtooth mini-peak" or gently "maxi-peak" folding of the retina. RPE adenoma often produces remote macular edema or epiretinal membrane and the tumor has an irregular, "rugged" surface with deep shadowing. Conclusions: Enhanced depth imaging optical coherence tomography shows characteristic patterns that are suggestive of certain retinal and RPE tumors. |
topic |
Ciliary body choroid eye iris melanoma metastasis prognosis tumor uvea Chemotherapy intravitreal chemotherapy intra-arterial chemotherapy intravenous chemotherapy periocular chemotherapy retinoblastoma Subtenon′s chemotherapy treatment Autoflouroscence enhanced depth imaging eye gene expression profiling malignancy metastasis monosomy 3 nevus optical coherence tomography tumor uveal melanoma Choroid enhanced depth imaging optical coherence tomography hemangioma lymphoma melanocytosis melanoma metastasis nevus osteoma tumor Choroid Eye metastases metastasis tumor uvea Astrocytic hamartoma enhanced depth imaging optical coherence tomography hemangioblastoma retina retinoblastoma tumor |
url |
http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=2;spage=128;epage=132;aulast=Shields |
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