The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives

The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives

Increased life expectancy in combination with modern life style and high prevalence of obesity are important risk factors for development of neurodegenerative diseases. Neuroinflammation is a feature of neurodegenerative diseases, and microglia, the innate immune cells of the brain, are central play...

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Bibliographic Details
Main Author: Vasileia Ismini Alexaki
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
obesity
microglia
neuroinflammation
neurodegeneration
systemic inflammation
insulin resistance
Online Access:https://www.mdpi.com/2073-4409/10/7/1584
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spelling doaj-2993a98052fc4edab24be59a0d01c15a2021-07-23T13:34:32ZengMDPI AGCells2073-44092021-06-01101584158410.3390/cells10071584The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine PerspectivesVasileia Ismini Alexaki0Institute for Clinical Chemistry and Laboratory Medicine, University Clinic Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, GermanyIncreased life expectancy in combination with modern life style and high prevalence of obesity are important risk factors for development of neurodegenerative diseases. Neuroinflammation is a feature of neurodegenerative diseases, and microglia, the innate immune cells of the brain, are central players in it. The present review discusses the effects of obesity, chronic peripheral inflammation and obesity-associated metabolic and endocrine perturbations, including insulin resistance, dyslipidemia and increased glucocorticoid levels, on microglial function.https://www.mdpi.com/2073-4409/10/7/1584obesitymicroglianeuroinflammationneurodegenerationsystemic inflammationinsulin resistance
collection DOAJ
language English
format Article
sources DOAJ
author Vasileia Ismini Alexaki
spellingShingle Vasileia Ismini Alexaki
The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
Cells
obesity
microglia
neuroinflammation
neurodegeneration
systemic inflammation
insulin resistance
author_facet Vasileia Ismini Alexaki
author_sort Vasileia Ismini Alexaki
title The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title_short The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title_full The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title_fullStr The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title_full_unstemmed The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives
title_sort impact of obesity on microglial function: immune, metabolic and endocrine perspectives
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2021-06-01
description Increased life expectancy in combination with modern life style and high prevalence of obesity are important risk factors for development of neurodegenerative diseases. Neuroinflammation is a feature of neurodegenerative diseases, and microglia, the innate immune cells of the brain, are central players in it. The present review discusses the effects of obesity, chronic peripheral inflammation and obesity-associated metabolic and endocrine perturbations, including insulin resistance, dyslipidemia and increased glucocorticoid levels, on microglial function.
topic obesity
microglia
neuroinflammation
neurodegeneration
systemic inflammation
insulin resistance
url https://www.mdpi.com/2073-4409/10/7/1584
work_keys_str_mv AT vasileiaisminialexaki theimpactofobesityonmicroglialfunctionimmunemetabolicandendocrineperspectives
AT vasileiaisminialexaki impactofobesityonmicroglialfunctionimmunemetabolicandendocrineperspectives
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