A New Rise of Non-Human Primate Models of Synucleinopathies
Synucleinopathies are neurodegenerative diseases characterized by the presence of α-synuclein-positive intracytoplasmic inclusions in the central nervous system. Multiple experimental models have been extensively used to understand better the mechanisms involved in the pathogenesis of synucleinopath...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-03-01
|
Series: | Biomedicines |
Subjects: | |
Online Access: | https://www.mdpi.com/2227-9059/9/3/272 |
id |
doaj-29a22b00a7ab46ccb96d261d21f3b13e |
---|---|
record_format |
Article |
spelling |
doaj-29a22b00a7ab46ccb96d261d21f3b13e2021-03-10T00:04:38ZengMDPI AGBiomedicines2227-90592021-03-01927227210.3390/biomedicines9030272A New Rise of Non-Human Primate Models of SynucleinopathiesMargaux Teil0Marie-Laure Arotcarena1Benjamin Dehay2Université de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, FranceUniversité de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, FranceUniversité de Bordeaux, CNRS, IMN, UMR 5293, F-33000 Bordeaux, FranceSynucleinopathies are neurodegenerative diseases characterized by the presence of α-synuclein-positive intracytoplasmic inclusions in the central nervous system. Multiple experimental models have been extensively used to understand better the mechanisms involved in the pathogenesis of synucleinopathy. Non-human primate (NHP) models are of interest in neurodegenerative diseases as they constitute the highest relevant preclinical model in translational research. They also contribute to bringing new insights into synucleinopathy’s pathogenicity and help in the quest and validation of therapeutical strategies. Here, we reviewed the different NHP models that have recapitulated key characteristics of synucleinopathy, and we aimed to highlight the contribution of NHP in mechanistic and translational approaches for synucleinopathies.https://www.mdpi.com/2227-9059/9/3/272non-human primatessynucleinopathyneurodegenerationα-synucleinanimal model |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Margaux Teil Marie-Laure Arotcarena Benjamin Dehay |
spellingShingle |
Margaux Teil Marie-Laure Arotcarena Benjamin Dehay A New Rise of Non-Human Primate Models of Synucleinopathies Biomedicines non-human primates synucleinopathy neurodegeneration α-synuclein animal model |
author_facet |
Margaux Teil Marie-Laure Arotcarena Benjamin Dehay |
author_sort |
Margaux Teil |
title |
A New Rise of Non-Human Primate Models of Synucleinopathies |
title_short |
A New Rise of Non-Human Primate Models of Synucleinopathies |
title_full |
A New Rise of Non-Human Primate Models of Synucleinopathies |
title_fullStr |
A New Rise of Non-Human Primate Models of Synucleinopathies |
title_full_unstemmed |
A New Rise of Non-Human Primate Models of Synucleinopathies |
title_sort |
new rise of non-human primate models of synucleinopathies |
publisher |
MDPI AG |
series |
Biomedicines |
issn |
2227-9059 |
publishDate |
2021-03-01 |
description |
Synucleinopathies are neurodegenerative diseases characterized by the presence of α-synuclein-positive intracytoplasmic inclusions in the central nervous system. Multiple experimental models have been extensively used to understand better the mechanisms involved in the pathogenesis of synucleinopathy. Non-human primate (NHP) models are of interest in neurodegenerative diseases as they constitute the highest relevant preclinical model in translational research. They also contribute to bringing new insights into synucleinopathy’s pathogenicity and help in the quest and validation of therapeutical strategies. Here, we reviewed the different NHP models that have recapitulated key characteristics of synucleinopathy, and we aimed to highlight the contribution of NHP in mechanistic and translational approaches for synucleinopathies. |
topic |
non-human primates synucleinopathy neurodegeneration α-synuclein animal model |
url |
https://www.mdpi.com/2227-9059/9/3/272 |
work_keys_str_mv |
AT margauxteil anewriseofnonhumanprimatemodelsofsynucleinopathies AT marielaurearotcarena anewriseofnonhumanprimatemodelsofsynucleinopathies AT benjamindehay anewriseofnonhumanprimatemodelsofsynucleinopathies AT margauxteil newriseofnonhumanprimatemodelsofsynucleinopathies AT marielaurearotcarena newriseofnonhumanprimatemodelsofsynucleinopathies AT benjamindehay newriseofnonhumanprimatemodelsofsynucleinopathies |
_version_ |
1724227125741879296 |