Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes.
Epstein-Barr Virus (EBV) causes infectious mononucleosis and establishes lifelong infection associated with cancer and autoimmune disease. To better understand immunity to EBV, we performed a prospective study of natural infection in healthy humans. Transcriptome analysis defined a striking and repr...
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doaj-29b9ab3f4bc1444faa96c8a2efcb52eb2020-11-25T02:52:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0191e8542210.1371/journal.pone.0085422Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes.Samantha K DunmireOludare A OdumadeJean L PorterJuan Reyes-GenereDavid O SchmelingHatice BilgicDanhua FanEmily C BaechlerHenry H BalfourKristin A HogquistEpstein-Barr Virus (EBV) causes infectious mononucleosis and establishes lifelong infection associated with cancer and autoimmune disease. To better understand immunity to EBV, we performed a prospective study of natural infection in healthy humans. Transcriptome analysis defined a striking and reproducible expression profile during acute infection but no lasting gene changes were apparent during latent infection. Comparing the EBV response profile to multiple other acute viral infections, including influenza A (influenza), respiratory syncytial virus (RSV), human rhinovirus (HRV), attenuated yellow fever virus (YFV), and Dengue fever virus (DENV), revealed similarity only to DENV. The signature shared by EBV and DENV was also present in patients with hemophagocytic syndromes, suggesting these two viruses cause uncontrolled inflammatory responses. Interestingly, while EBV induced a strong type I interferon response, a subset of interferon induced genes, including MX1, HERC5, and OAS1, were not upregulated, suggesting a mechanism by which viral antagonism of immunity results in a profound inflammatory response. These data provide an important first description of the response to a natural herpesvirus infection in humans.http://europepmc.org/articles/PMC3894977?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Samantha K Dunmire Oludare A Odumade Jean L Porter Juan Reyes-Genere David O Schmeling Hatice Bilgic Danhua Fan Emily C Baechler Henry H Balfour Kristin A Hogquist |
spellingShingle |
Samantha K Dunmire Oludare A Odumade Jean L Porter Juan Reyes-Genere David O Schmeling Hatice Bilgic Danhua Fan Emily C Baechler Henry H Balfour Kristin A Hogquist Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes. PLoS ONE |
author_facet |
Samantha K Dunmire Oludare A Odumade Jean L Porter Juan Reyes-Genere David O Schmeling Hatice Bilgic Danhua Fan Emily C Baechler Henry H Balfour Kristin A Hogquist |
author_sort |
Samantha K Dunmire |
title |
Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes. |
title_short |
Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes. |
title_full |
Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes. |
title_fullStr |
Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes. |
title_full_unstemmed |
Primary EBV infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes. |
title_sort |
primary ebv infection induces an expression profile distinct from other viruses but similar to hemophagocytic syndromes. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
Epstein-Barr Virus (EBV) causes infectious mononucleosis and establishes lifelong infection associated with cancer and autoimmune disease. To better understand immunity to EBV, we performed a prospective study of natural infection in healthy humans. Transcriptome analysis defined a striking and reproducible expression profile during acute infection but no lasting gene changes were apparent during latent infection. Comparing the EBV response profile to multiple other acute viral infections, including influenza A (influenza), respiratory syncytial virus (RSV), human rhinovirus (HRV), attenuated yellow fever virus (YFV), and Dengue fever virus (DENV), revealed similarity only to DENV. The signature shared by EBV and DENV was also present in patients with hemophagocytic syndromes, suggesting these two viruses cause uncontrolled inflammatory responses. Interestingly, while EBV induced a strong type I interferon response, a subset of interferon induced genes, including MX1, HERC5, and OAS1, were not upregulated, suggesting a mechanism by which viral antagonism of immunity results in a profound inflammatory response. These data provide an important first description of the response to a natural herpesvirus infection in humans. |
url |
http://europepmc.org/articles/PMC3894977?pdf=render |
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