Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans
Transcranial focused ultrasound (tFUS) is an emerging method for non-invasive neuromodulation akin to transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). tFUS offers several advantages over electromagnetic methods including high spatial resolution and the abil...
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doaj-29ba65a66260424888169e76440123762020-11-25T02:20:24ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612020-02-011410.3389/fnhum.2020.00052494085Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in HumansJoseph L. Sanguinetti0Joseph L. Sanguinetti1Joseph L. Sanguinetti2Stuart Hameroff3Stuart Hameroff4Stuart Hameroff5Ezra E. Smith6Ezra E. Smith7Tomokazu Sato8Chris M. W. Daft9William J. Tyler10John J. B. Allen11Department of Psychology, University of Arizona, Tucson, AZ, United StatesCenter for Consciousness Studies, University of Arizona, Tucson, AZ, United StatesDepartment of Psychology, The University of New Mexico, Albuquerque, NM, United StatesDepartment of Psychology, University of Arizona, Tucson, AZ, United StatesCenter for Consciousness Studies, University of Arizona, Tucson, AZ, United StatesDepartment of Anesthesiology, University of Arizona, Tucson, AZ, United StatesDepartment of Psychology, University of Arizona, Tucson, AZ, United StatesNew York State Psychiatric Institute, New York, NY, United StatesThe Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United StatesRiver Sonic Solutions LLC, San Francisco, CA, United StatesSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United StatesDepartment of Psychology, University of Arizona, Tucson, AZ, United StatesTranscranial focused ultrasound (tFUS) is an emerging method for non-invasive neuromodulation akin to transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). tFUS offers several advantages over electromagnetic methods including high spatial resolution and the ability to reach deep brain targets. Here we describe two experiments assessing whether tFUS could modulate mood in healthy human volunteers by targeting the right inferior frontal gyrus (rIFG), an area implicated in mood and emotional regulation. In a randomized, placebo-controlled, double-blind study, participants received 30 s of 500 kHz tFUS or a placebo control. Visual Analog Mood Scales (VAMS) assessed mood four times within an hour (baseline and three times after tFUS). Participants who received tFUS reported an overall increase in Global Affect (GA), an aggregate score from the VAMS scale, indicating a positive shift in mood. Experiment 2 examined resting-state functional (FC) connectivity using functional magnetic resonance imaging (fMRI) following 2 min of 500 kHz tFUS at the rIFG. As in Experiment 1, tFUS enhanced self-reported mood states and also decreased FC in resting state networks related to emotion and mood regulation. These results suggest that tFUS can be used to modulate mood and emotional regulation networks in the prefrontal cortex.https://www.frontiersin.org/article/10.3389/fnhum.2020.00052/fulltranscranial focused ultrasoundneuromodulationmoodfunctional connectivitybrain stimulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joseph L. Sanguinetti Joseph L. Sanguinetti Joseph L. Sanguinetti Stuart Hameroff Stuart Hameroff Stuart Hameroff Ezra E. Smith Ezra E. Smith Tomokazu Sato Chris M. W. Daft William J. Tyler John J. B. Allen |
spellingShingle |
Joseph L. Sanguinetti Joseph L. Sanguinetti Joseph L. Sanguinetti Stuart Hameroff Stuart Hameroff Stuart Hameroff Ezra E. Smith Ezra E. Smith Tomokazu Sato Chris M. W. Daft William J. Tyler John J. B. Allen Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans Frontiers in Human Neuroscience transcranial focused ultrasound neuromodulation mood functional connectivity brain stimulation |
author_facet |
Joseph L. Sanguinetti Joseph L. Sanguinetti Joseph L. Sanguinetti Stuart Hameroff Stuart Hameroff Stuart Hameroff Ezra E. Smith Ezra E. Smith Tomokazu Sato Chris M. W. Daft William J. Tyler John J. B. Allen |
author_sort |
Joseph L. Sanguinetti |
title |
Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans |
title_short |
Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans |
title_full |
Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans |
title_fullStr |
Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans |
title_full_unstemmed |
Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans |
title_sort |
transcranial focused ultrasound to the right prefrontal cortex improves mood and alters functional connectivity in humans |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2020-02-01 |
description |
Transcranial focused ultrasound (tFUS) is an emerging method for non-invasive neuromodulation akin to transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). tFUS offers several advantages over electromagnetic methods including high spatial resolution and the ability to reach deep brain targets. Here we describe two experiments assessing whether tFUS could modulate mood in healthy human volunteers by targeting the right inferior frontal gyrus (rIFG), an area implicated in mood and emotional regulation. In a randomized, placebo-controlled, double-blind study, participants received 30 s of 500 kHz tFUS or a placebo control. Visual Analog Mood Scales (VAMS) assessed mood four times within an hour (baseline and three times after tFUS). Participants who received tFUS reported an overall increase in Global Affect (GA), an aggregate score from the VAMS scale, indicating a positive shift in mood. Experiment 2 examined resting-state functional (FC) connectivity using functional magnetic resonance imaging (fMRI) following 2 min of 500 kHz tFUS at the rIFG. As in Experiment 1, tFUS enhanced self-reported mood states and also decreased FC in resting state networks related to emotion and mood regulation. These results suggest that tFUS can be used to modulate mood and emotional regulation networks in the prefrontal cortex. |
topic |
transcranial focused ultrasound neuromodulation mood functional connectivity brain stimulation |
url |
https://www.frontiersin.org/article/10.3389/fnhum.2020.00052/full |
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