Repurposing Ferumoxytol as a Breast Cancer-Associated Macrophage Tracer with Five-Dimensional Quantitative [Fe]MRI of SPION Dynamics
Tumor-associated macrophages (TAMs) in breast cancer regulate inflammation, immunosuppression, angiogenesis, and metastasis. However, TAM imaging remains a clinical challenge. Ferumoxytol has long been an FDA-approved superparamagnetic iron oxide nanoparticle (SPION) preparation used as an intraveno...
Main Authors: | Laurel O. Sillerud, Alexander J. Neuwelt, Fernanda I. Staquicini, Wadih Arap, Renata Pasqualini |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-07-01
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Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/13/15/3802 |
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