Hiding in Plain Sight: Epigenetic Plasticity in Drug-Induced Tumor Evolution
Cancer is a heterogeneous disease with key differences at the cellular and molecular levels. Acquisition of these differences during the course of tumor development manifests into functional and phenotypic heterogeneity leading to tumor diversity, also referred to as intra-tumor heterogeneity (ITH)....
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2019-08-01
|
Series: | Epigenetics Insights |
Online Access: | https://doi.org/10.1177/2516865719870760 |
id |
doaj-29cc54d1a4b34e15bfd99c094044d303 |
---|---|
record_format |
Article |
spelling |
doaj-29cc54d1a4b34e15bfd99c094044d3032020-11-25T02:54:34ZengSAGE PublishingEpigenetics Insights2516-86572019-08-011210.1177/2516865719870760Hiding in Plain Sight: Epigenetic Plasticity in Drug-Induced Tumor EvolutionAnkur SharmaCancer is a heterogeneous disease with key differences at the cellular and molecular levels. Acquisition of these differences during the course of tumor development manifests into functional and phenotypic heterogeneity leading to tumor diversity, also referred to as intra-tumor heterogeneity (ITH). Within a tumor, there are subpopulations of cells capable of tumor initiation and maintenance. These cells often exhibit resistance to standard-of-care anti-cancer drugs. However, the role of various subpopulations (clones) in drug resistance remains to be investigated. Moreover, the jury is still out about whether drug resistance is a result of clonal selection of preexisting cells, or the cells acquire resistance by dynamic re-wiring of their epigenome. Therefore, we investigated the drug-induced tumor evolution in patient-derived primary cells of head and neck squamous cell carcinoma. Our data demonstrated the role of a preexisting poised epigenetic state in drug-induced adaptive evolution of tumor cells. Importantly, the combination of chemotherapy and epigenetic inhibitors can prevent/delay drug-induced tumor evolution.https://doi.org/10.1177/2516865719870760 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ankur Sharma |
spellingShingle |
Ankur Sharma Hiding in Plain Sight: Epigenetic Plasticity in Drug-Induced Tumor Evolution Epigenetics Insights |
author_facet |
Ankur Sharma |
author_sort |
Ankur Sharma |
title |
Hiding in Plain Sight: Epigenetic Plasticity in Drug-Induced Tumor Evolution |
title_short |
Hiding in Plain Sight: Epigenetic Plasticity in Drug-Induced Tumor Evolution |
title_full |
Hiding in Plain Sight: Epigenetic Plasticity in Drug-Induced Tumor Evolution |
title_fullStr |
Hiding in Plain Sight: Epigenetic Plasticity in Drug-Induced Tumor Evolution |
title_full_unstemmed |
Hiding in Plain Sight: Epigenetic Plasticity in Drug-Induced Tumor Evolution |
title_sort |
hiding in plain sight: epigenetic plasticity in drug-induced tumor evolution |
publisher |
SAGE Publishing |
series |
Epigenetics Insights |
issn |
2516-8657 |
publishDate |
2019-08-01 |
description |
Cancer is a heterogeneous disease with key differences at the cellular and molecular levels. Acquisition of these differences during the course of tumor development manifests into functional and phenotypic heterogeneity leading to tumor diversity, also referred to as intra-tumor heterogeneity (ITH). Within a tumor, there are subpopulations of cells capable of tumor initiation and maintenance. These cells often exhibit resistance to standard-of-care anti-cancer drugs. However, the role of various subpopulations (clones) in drug resistance remains to be investigated. Moreover, the jury is still out about whether drug resistance is a result of clonal selection of preexisting cells, or the cells acquire resistance by dynamic re-wiring of their epigenome. Therefore, we investigated the drug-induced tumor evolution in patient-derived primary cells of head and neck squamous cell carcinoma. Our data demonstrated the role of a preexisting poised epigenetic state in drug-induced adaptive evolution of tumor cells. Importantly, the combination of chemotherapy and epigenetic inhibitors can prevent/delay drug-induced tumor evolution. |
url |
https://doi.org/10.1177/2516865719870760 |
work_keys_str_mv |
AT ankursharma hidinginplainsightepigeneticplasticityindruginducedtumorevolution |
_version_ |
1724720233983246336 |