The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis
The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway plays a pivotal role within these pr...
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doaj-29e0beb437414fe39513756aa02705b52021-09-25T05:11:11ZengElsevierJournal of Translational Autoimmunity2589-90902021-01-014100123The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosisDaphne Peerlings0Max Mimpen1Jan Damoiseaux2Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the NetherlandsSchool for Mental Health and Neuroscience, University of Maastricht, Maastricht, the NetherlandsCentral Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands; Corresponding author. Central Diagnostic Laboratory, Maastricht University Medical Center, P. Debyelaan 25, 6229, HX, Maastricht, the Netherlands.The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway plays a pivotal role within these processes. The most striking functions of the IL-2 – IL-2R pathway are the differential induction of autoimmune responses and tolerance. This paradoxical function of the IL-2 – IL-2R pathway may be an attractive therapeutic target for autoimmune diseases such as MS. However, the exact mechanisms that lead to autoimmunity or tolerance remain to be elucidated. Furthermore, another factor of this pathway, the soluble form of the IL-2R (sIL-2R), further complicates understanding the role of the IL-2 – IL-2R pathway in MS. The challenge is to unravel these mechanisms to prevent, diagnose and recover MS. In this review, first, the current knowledge of MS and the IL-2 – IL-2R pathway are summarized. Second, the key findings of the relation between the IL-2 – IL-2R pathway and MS have been highlighted. Eventually, this review may launch broad interest in the IL-2 – IL-2R pathway propelling further research in autoimmune diseases, including MS.http://www.sciencedirect.com/science/article/pii/S2589909021000435Multiple sclerosisInterleukin 2Interleukin 2 receptorSoluble interleukin 2 receptor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daphne Peerlings Max Mimpen Jan Damoiseaux |
spellingShingle |
Daphne Peerlings Max Mimpen Jan Damoiseaux The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis Journal of Translational Autoimmunity Multiple sclerosis Interleukin 2 Interleukin 2 receptor Soluble interleukin 2 receptor |
author_facet |
Daphne Peerlings Max Mimpen Jan Damoiseaux |
author_sort |
Daphne Peerlings |
title |
The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis |
title_short |
The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis |
title_full |
The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis |
title_fullStr |
The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis |
title_full_unstemmed |
The IL-2 – IL-2 receptor pathway: Key to understanding multiple sclerosis |
title_sort |
il-2 – il-2 receptor pathway: key to understanding multiple sclerosis |
publisher |
Elsevier |
series |
Journal of Translational Autoimmunity |
issn |
2589-9090 |
publishDate |
2021-01-01 |
description |
The development, progression, diagnosis and treatment of autoimmune diseases, such as multiple sclerosis (MS), are convoluted processes which remain incompletely understood. Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway plays a pivotal role within these processes. The most striking functions of the IL-2 – IL-2R pathway are the differential induction of autoimmune responses and tolerance. This paradoxical function of the IL-2 – IL-2R pathway may be an attractive therapeutic target for autoimmune diseases such as MS. However, the exact mechanisms that lead to autoimmunity or tolerance remain to be elucidated. Furthermore, another factor of this pathway, the soluble form of the IL-2R (sIL-2R), further complicates understanding the role of the IL-2 – IL-2R pathway in MS. The challenge is to unravel these mechanisms to prevent, diagnose and recover MS. In this review, first, the current knowledge of MS and the IL-2 – IL-2R pathway are summarized. Second, the key findings of the relation between the IL-2 – IL-2R pathway and MS have been highlighted. Eventually, this review may launch broad interest in the IL-2 – IL-2R pathway propelling further research in autoimmune diseases, including MS. |
topic |
Multiple sclerosis Interleukin 2 Interleukin 2 receptor Soluble interleukin 2 receptor |
url |
http://www.sciencedirect.com/science/article/pii/S2589909021000435 |
work_keys_str_mv |
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