Engineering modular intracellular protein sensor-actuator devices

Engineering modular intracellular protein sensor-actuator devices

Synthetic biology principles are often used to design circuits that tune gene expression in response to changes in intracellular environments. Here the authors design a modular platform for intracellular protein sensing devices with transcriptional output.

Bibliographic Details
Main Authors: Velia Siciliano, Breanna DiAndreth, Blandine Monel, Jacob Beal, Jin Huh, Kiera L Clayton, Liliana Wroblewska, AnneMarie McKeon, Bruce D. Walker, Ron Weiss
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03984-5
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spelling doaj-29e185b3e05642a993be2f596425ebc82021-05-11T09:50:47ZengNature Publishing GroupNature Communications2041-17232018-05-01911710.1038/s41467-018-03984-5Engineering modular intracellular protein sensor-actuator devicesVelia Siciliano0Breanna DiAndreth1Blandine Monel2Jacob Beal3Jin Huh4Kiera L Clayton5Liliana Wroblewska6AnneMarie McKeon7Bruce D. Walker8Ron Weiss9Department of Synthetic and Systems Biology for Biomedicine, Istituto Italiano di TecnologiaDepartment of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of TechnologyRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard UniversityRaytheon BBN TechnologiesDepartment of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of TechnologyRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard UniversityPfizerRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard UniversityRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard UniversityDepartment of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of TechnologySynthetic biology principles are often used to design circuits that tune gene expression in response to changes in intracellular environments. Here the authors design a modular platform for intracellular protein sensing devices with transcriptional output.https://doi.org/10.1038/s41467-018-03984-5
collection DOAJ
language English
format Article
sources DOAJ
author Velia Siciliano
Breanna DiAndreth
Blandine Monel
Jacob Beal
Jin Huh
Kiera L Clayton
Liliana Wroblewska
AnneMarie McKeon
Bruce D. Walker
Ron Weiss
spellingShingle Velia Siciliano
Breanna DiAndreth
Blandine Monel
Jacob Beal
Jin Huh
Kiera L Clayton
Liliana Wroblewska
AnneMarie McKeon
Bruce D. Walker
Ron Weiss
Engineering modular intracellular protein sensor-actuator devices
Nature Communications
author_facet Velia Siciliano
Breanna DiAndreth
Blandine Monel
Jacob Beal
Jin Huh
Kiera L Clayton
Liliana Wroblewska
AnneMarie McKeon
Bruce D. Walker
Ron Weiss
author_sort Velia Siciliano
title Engineering modular intracellular protein sensor-actuator devices
title_short Engineering modular intracellular protein sensor-actuator devices
title_full Engineering modular intracellular protein sensor-actuator devices
title_fullStr Engineering modular intracellular protein sensor-actuator devices
title_full_unstemmed Engineering modular intracellular protein sensor-actuator devices
title_sort engineering modular intracellular protein sensor-actuator devices
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-05-01
description Synthetic biology principles are often used to design circuits that tune gene expression in response to changes in intracellular environments. Here the authors design a modular platform for intracellular protein sensing devices with transcriptional output.
url https://doi.org/10.1038/s41467-018-03984-5
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AT breannadiandreth engineeringmodularintracellularproteinsensoractuatordevices
AT blandinemonel engineeringmodularintracellularproteinsensoractuatordevices
AT jacobbeal engineeringmodularintracellularproteinsensoractuatordevices
AT jinhuh engineeringmodularintracellularproteinsensoractuatordevices
AT kieralclayton engineeringmodularintracellularproteinsensoractuatordevices
AT lilianawroblewska engineeringmodularintracellularproteinsensoractuatordevices
AT annemariemckeon engineeringmodularintracellularproteinsensoractuatordevices
AT brucedwalker engineeringmodularintracellularproteinsensoractuatordevices
AT ronweiss engineeringmodularintracellularproteinsensoractuatordevices
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