Quinacrine-Induced Autophagy in Ovarian Cancer Triggers Cathepsin-L Mediated Lysosomal/Mitochondrial Membrane Permeabilization and Cell Death

Quinacrine-Induced Autophagy in Ovarian Cancer Triggers Cathepsin-L Mediated Lysosomal/Mitochondrial Membrane Permeabilization and Cell Death

We previously reported that the antimalarial compound quinacrine (QC) induces autophagy in ovarian cancer cells. In the current study, we uncovered that QC significantly upregulates cathepsin L (CTSL) but not cathepsin B and D levels, implicating the specific role of CTSL in promoting QC-induced aut...

Full description

Bibliographic Details
Main Authors: Prabhu Thirusangu, Christopher L. Pathoulas, Upasana Ray, Yinan Xiao, Julie Staub, Ling Jin, Ashwani Khurana, Viji Shridhar
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
quinacrine
autophagy
CTSL
LMP
MOMP
ovarian cancer
Online Access:https://www.mdpi.com/2072-6694/13/9/2004

Internet

https://www.mdpi.com/2072-6694/13/9/2004

Similar Items