Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway
The water channel AQP2 mediates the concentration of urine in the kidney. Here Ando et al. show that Wnt5 promotes collecting duct permeability by regulating AQP2 expression and localization through activation of the calmodulin/calcineurin signalling pathway.
Bibliographic Details
| Main Authors: |
Fumiaki Ando,
Eisei Sohara,
Tetsuji Morimoto,
Naofumi Yui,
Naohiro Nomura,
Eriko Kikuchi,
Daiei Takahashi,
Takayasu Mori,
Alain Vandewalle,
Tatemitsu Rai,
Sei Sasaki,
Yoshiaki Kondo,
Shinichi Uchida |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms13636
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