CRISPR-Cas13a mediated targeting of hepatitis C virus internal-ribosomal entry site (IRES) as an effective antiviral strategy

CRISPR-Cas13a mediated targeting of hepatitis C virus internal-ribosomal entry site (IRES) as an effective antiviral strategy

Hepatitis C is an inflammatory liver disease caused by the single-stranded RNA (ssRNA) hepatitis C virus (HCV). The genetic diversity of the virus and quasispecies produced during replication have resulted in viral resistance to direct-acting antivirals (DAAs) as well as impediments in vaccine devel...

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Bibliographic Details
Main Authors: Muhammad Usman Ashraf, Hafiz Muhammad Salman, Muhammad Farhan Khalid, Muhammad Haider Farooq Khan, Saima Anwar, Samia Afzal, Muhammad Idrees, Safee Ullah Chaudhary
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
HCV IRES inhibition
CRISPR Cas13
CRISPRi
Antiviral treatment
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222100024X

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