Serum lipid profile in patients with cholesterol containing gallstones: A study from South India
Background: Cholelithiasis is a common disease and notable advances have been made in studying the possible causes and mechanisms involved. It is not only important to study the prevalence of gallstone disease regionally, but also to explore the demographic and biological markers related to the deve...
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Wolters Kluwer Medknow Publications
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doaj-29ea26324b56483c90b73c64260b38af2021-07-07T14:19:06ZengWolters Kluwer Medknow PublicationsMGM Journal of Medical Sciences2347-79462347-79622020-01-0172636710.4103/mgmj.MGMJ_42_20Serum lipid profile in patients with cholesterol containing gallstones: A study from South IndiaPrema SaldanhaPriya SunejaAnand RajBackground: Cholelithiasis is a common disease and notable advances have been made in studying the possible causes and mechanisms involved. It is not only important to study the prevalence of gallstone disease regionally, but also to explore the demographic and biological markers related to the development of gallstone disease, so that appropriate preventive measures may be undertaken. Many previous studies have shown a positive correlation between altered lipid profile and formation of gallstones, whereas some show no definite correlation between the two. Objective: This work aimed to study the association of lipid profile with cholelithiasis in our geographic region. Materials and Methods: This was a retrospective study of cases who underwent cholecystectomy for cholelithiasis, obtained from the archives of the Department of Pathology. The lipid profiles of these patients were retrieved from the laboratory records and analyzed. Results: The number of patients with mixed stones (cholesterol and pigment) accounted for 85% and pure cholesterol stones were seen 15% of the cases. Deranged lipid profile was observed in 57 (95%) of the cases. The most common abnormality was increased levels of low-density lipoprotein /very low density lipoprotein with decreased high-density lipoprotein. Conclusion: In this study, it was found that a significant number of patients with cholesterol-containing stones had a deranged lipid profile. This suggests that hyperlipidemia plays an important role in the lithogenesis of cholesterol-rich gallstones.http://www.mgmjms.com/article.asp?issn=2347-7946;year=2020;volume=7;issue=2;spage=63;epage=67;aulast=Saldanhacholesterol stonesgallstoneslipid profile |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Prema Saldanha Priya Suneja Anand Raj |
spellingShingle |
Prema Saldanha Priya Suneja Anand Raj Serum lipid profile in patients with cholesterol containing gallstones: A study from South India MGM Journal of Medical Sciences cholesterol stones gallstones lipid profile |
author_facet |
Prema Saldanha Priya Suneja Anand Raj |
author_sort |
Prema Saldanha |
title |
Serum lipid profile in patients with cholesterol containing gallstones: A study from South India |
title_short |
Serum lipid profile in patients with cholesterol containing gallstones: A study from South India |
title_full |
Serum lipid profile in patients with cholesterol containing gallstones: A study from South India |
title_fullStr |
Serum lipid profile in patients with cholesterol containing gallstones: A study from South India |
title_full_unstemmed |
Serum lipid profile in patients with cholesterol containing gallstones: A study from South India |
title_sort |
serum lipid profile in patients with cholesterol containing gallstones: a study from south india |
publisher |
Wolters Kluwer Medknow Publications |
series |
MGM Journal of Medical Sciences |
issn |
2347-7946 2347-7962 |
publishDate |
2020-01-01 |
description |
Background: Cholelithiasis is a common disease and notable advances have been made in studying the possible causes and mechanisms involved. It is not only important to study the prevalence of gallstone disease regionally, but also to explore the demographic and biological markers related to the development of gallstone disease, so that appropriate preventive measures may be undertaken. Many previous studies have shown a positive correlation between altered lipid profile and formation of gallstones, whereas some show no definite correlation between the two. Objective: This work aimed to study the association of lipid profile with cholelithiasis in our geographic region. Materials and Methods: This was a retrospective study of cases who underwent cholecystectomy for cholelithiasis, obtained from the archives of the Department of Pathology. The lipid profiles of these patients were retrieved from the laboratory records and analyzed. Results: The number of patients with mixed stones (cholesterol and pigment) accounted for 85% and pure cholesterol stones were seen 15% of the cases. Deranged lipid profile was observed in 57 (95%) of the cases. The most common abnormality was increased levels of low-density lipoprotein /very low density lipoprotein with decreased high-density lipoprotein. Conclusion: In this study, it was found that a significant number of patients with cholesterol-containing stones had a deranged lipid profile. This suggests that hyperlipidemia plays an important role in the lithogenesis of cholesterol-rich gallstones. |
topic |
cholesterol stones gallstones lipid profile |
url |
http://www.mgmjms.com/article.asp?issn=2347-7946;year=2020;volume=7;issue=2;spage=63;epage=67;aulast=Saldanha |
work_keys_str_mv |
AT premasaldanha serumlipidprofileinpatientswithcholesterolcontaininggallstonesastudyfromsouthindia AT priyasuneja serumlipidprofileinpatientswithcholesterolcontaininggallstonesastudyfromsouthindia AT anandraj serumlipidprofileinpatientswithcholesterolcontaininggallstonesastudyfromsouthindia |
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1721315342426308608 |