Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein

Summary. Thrombosis is a serious complication of a hyaluronic acid-based filler injection. Little is known about the late-onset complications of fillers; therefore, an optimal complication management is necessary. In this case report, we describe a rare complication of thrombosis after a filler inje...

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Main Authors:	Jennis Gabrielpillai, MD, Arash Salamat, MD, Christian Schaefer, MD, Alexander Kania, MD, Christian Lunatschek, MD, Klaus Wolfgang Eichhorn, MD, Friedrich Bootz, MD, Thorsten Send, MD
Format:	Article
Language:	English
Published:	Wolters Kluwer 2020-11-01
Series:	Plastic and Reconstructive Surgery, Global Open
Online Access:	http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000003216

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spelling	doaj-29ee84f335f849d09c9b532c66af8e3d2020-12-10T08:42:33ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742020-11-01811e321610.1097/GOX.0000000000003216202011000-00014Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal VeinJennis Gabrielpillai, MD0Arash Salamat, MD1Christian Schaefer, MD2Alexander Kania, MD3Christian Lunatschek, MD4Klaus Wolfgang Eichhorn, MD5Friedrich Bootz, MD6Thorsten Send, MD7* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany† Medical Clinic II, Cardiology, Pneumology and Angiology, University Hospital Bonn, Bonn, Germany‡ Department of Vascular Surgery, University Hospital Bonn, Bonn, Germany.* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, GermanySummary. Thrombosis is a serious complication of a hyaluronic acid-based filler injection. Little is known about the late-onset complications of fillers; therefore, an optimal complication management is necessary. In this case report, we describe a rare complication of thrombosis after a filler injection. A 35-year old woman was admitted to the emergency department, with swelling on her forehead in association with recurrent pain and light flashes in her right eye. Sonographic examination showed a thrombosis of the right frontal vein. The patient reported that a hyaluronic acid filler injection had been administered on the forehead 3 months ago. After several weeks of anticoagulation with heparin and apixaban, the symptoms persisted. The vein with thrombosis was ultimately resected under local anesthesia. Histological findings showed a chronic inflammatory reaction of the tissue to hyaluronic acid. Vascular complications may appear as late-onset complications even several months after the filler injection. Subcutaneous application of low molecular weight heparins is the therapy of first choice. If this treatment is not effective, resection of the thrombosis may be performed.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000003216
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jennis Gabrielpillai, MD Arash Salamat, MD Christian Schaefer, MD Alexander Kania, MD Christian Lunatschek, MD Klaus Wolfgang Eichhorn, MD Friedrich Bootz, MD Thorsten Send, MD
spellingShingle	Jennis Gabrielpillai, MD Arash Salamat, MD Christian Schaefer, MD Alexander Kania, MD Christian Lunatschek, MD Klaus Wolfgang Eichhorn, MD Friedrich Bootz, MD Thorsten Send, MD Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein Plastic and Reconstructive Surgery, Global Open
author_facet	Jennis Gabrielpillai, MD Arash Salamat, MD Christian Schaefer, MD Alexander Kania, MD Christian Lunatschek, MD Klaus Wolfgang Eichhorn, MD Friedrich Bootz, MD Thorsten Send, MD
author_sort	Jennis Gabrielpillai, MD
title	Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein
title_short	Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein
title_full	Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein
title_fullStr	Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein
title_full_unstemmed	Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein
title_sort	hyaluronic acid-based filler injection: late-onset thrombosis of the frontal vein
publisher	Wolters Kluwer
series	Plastic and Reconstructive Surgery, Global Open
issn	2169-7574
publishDate	2020-11-01
description	Summary. Thrombosis is a serious complication of a hyaluronic acid-based filler injection. Little is known about the late-onset complications of fillers; therefore, an optimal complication management is necessary. In this case report, we describe a rare complication of thrombosis after a filler injection. A 35-year old woman was admitted to the emergency department, with swelling on her forehead in association with recurrent pain and light flashes in her right eye. Sonographic examination showed a thrombosis of the right frontal vein. The patient reported that a hyaluronic acid filler injection had been administered on the forehead 3 months ago. After several weeks of anticoagulation with heparin and apixaban, the symptoms persisted. The vein with thrombosis was ultimately resected under local anesthesia. Histological findings showed a chronic inflammatory reaction of the tissue to hyaluronic acid. Vascular complications may appear as late-onset complications even several months after the filler injection. Subcutaneous application of low molecular weight heparins is the therapy of first choice. If this treatment is not effective, resection of the thrombosis may be performed.
url	http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000003216
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Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein

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