Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein
Summary. Thrombosis is a serious complication of a hyaluronic acid-based filler injection. Little is known about the late-onset complications of fillers; therefore, an optimal complication management is necessary. In this case report, we describe a rare complication of thrombosis after a filler inje...
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Wolters Kluwer
2020-11-01
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doaj-29ee84f335f849d09c9b532c66af8e3d2020-12-10T08:42:33ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742020-11-01811e321610.1097/GOX.0000000000003216202011000-00014Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal VeinJennis Gabrielpillai, MD0Arash Salamat, MD1Christian Schaefer, MD2Alexander Kania, MD3Christian Lunatschek, MD4Klaus Wolfgang Eichhorn, MD5Friedrich Bootz, MD6Thorsten Send, MD7* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany† Medical Clinic II, Cardiology, Pneumology and Angiology, University Hospital Bonn, Bonn, Germany‡ Department of Vascular Surgery, University Hospital Bonn, Bonn, Germany.* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany* Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, GermanySummary. Thrombosis is a serious complication of a hyaluronic acid-based filler injection. Little is known about the late-onset complications of fillers; therefore, an optimal complication management is necessary. In this case report, we describe a rare complication of thrombosis after a filler injection. A 35-year old woman was admitted to the emergency department, with swelling on her forehead in association with recurrent pain and light flashes in her right eye. Sonographic examination showed a thrombosis of the right frontal vein. The patient reported that a hyaluronic acid filler injection had been administered on the forehead 3 months ago. After several weeks of anticoagulation with heparin and apixaban, the symptoms persisted. The vein with thrombosis was ultimately resected under local anesthesia. Histological findings showed a chronic inflammatory reaction of the tissue to hyaluronic acid. Vascular complications may appear as late-onset complications even several months after the filler injection. Subcutaneous application of low molecular weight heparins is the therapy of first choice. If this treatment is not effective, resection of the thrombosis may be performed.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000003216 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jennis Gabrielpillai, MD Arash Salamat, MD Christian Schaefer, MD Alexander Kania, MD Christian Lunatschek, MD Klaus Wolfgang Eichhorn, MD Friedrich Bootz, MD Thorsten Send, MD |
spellingShingle |
Jennis Gabrielpillai, MD Arash Salamat, MD Christian Schaefer, MD Alexander Kania, MD Christian Lunatschek, MD Klaus Wolfgang Eichhorn, MD Friedrich Bootz, MD Thorsten Send, MD Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein Plastic and Reconstructive Surgery, Global Open |
author_facet |
Jennis Gabrielpillai, MD Arash Salamat, MD Christian Schaefer, MD Alexander Kania, MD Christian Lunatschek, MD Klaus Wolfgang Eichhorn, MD Friedrich Bootz, MD Thorsten Send, MD |
author_sort |
Jennis Gabrielpillai, MD |
title |
Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein |
title_short |
Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein |
title_full |
Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein |
title_fullStr |
Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein |
title_full_unstemmed |
Hyaluronic Acid-based Filler Injection: Late-onset Thrombosis of the Frontal Vein |
title_sort |
hyaluronic acid-based filler injection: late-onset thrombosis of the frontal vein |
publisher |
Wolters Kluwer |
series |
Plastic and Reconstructive Surgery, Global Open |
issn |
2169-7574 |
publishDate |
2020-11-01 |
description |
Summary. Thrombosis is a serious complication of a hyaluronic acid-based filler injection. Little is known about the late-onset complications of fillers; therefore, an optimal complication management is necessary. In this case report, we describe a rare complication of thrombosis after a filler injection. A 35-year old woman was admitted to the emergency department, with swelling on her forehead in association with recurrent pain and light flashes in her right eye. Sonographic examination showed a thrombosis of the right frontal vein. The patient reported that a hyaluronic acid filler injection had been administered on the forehead 3 months ago. After several weeks of anticoagulation with heparin and apixaban, the symptoms persisted. The vein with thrombosis was ultimately resected under local anesthesia. Histological findings showed a chronic inflammatory reaction of the tissue to hyaluronic acid. Vascular complications may appear as late-onset complications even several months after the filler injection. Subcutaneous application of low molecular weight heparins is the therapy of first choice. If this treatment is not effective, resection of the thrombosis may be performed. |
url |
http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000003216 |
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