Water-dispersible unadulterated α-mangostin particles for biomedical applications
α-Mangostin, the extract from pericarp of Garcinia mangostana L. or mangosteen fruit, has been applied in various biomedical products because of its minimal skin irritation, and prominent anti-inflammatory, antimicrobial and immune-modulating activities. Owing to its low water solubility, the partic...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
The Royal Society
2020-11-01
|
Series: | Royal Society Open Science |
Subjects: | |
Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200543 |
id |
doaj-29f42a4b29d14fe4a308154cf14cee4d |
---|---|
record_format |
Article |
spelling |
doaj-29f42a4b29d14fe4a308154cf14cee4d2021-01-15T15:05:37ZengThe Royal SocietyRoyal Society Open Science2054-57032020-11-0171110.1098/rsos.200543200543Water-dispersible unadulterated α-mangostin particles for biomedical applicationsJutamad BumrungChanpen ChanchaoVarol IntasantaTanapat PalagaSupason Wanichwecharungruangα-Mangostin, the extract from pericarp of Garcinia mangostana L. or mangosteen fruit, has been applied in various biomedical products because of its minimal skin irritation, and prominent anti-inflammatory, antimicrobial and immune-modulating activities. Owing to its low water solubility, the particle formulations are necessary for the applications of α-mangostin in aqueous media. The particle formulations are usually prepared using surfactants and/or polymers, usually at a larger amount of these auxiliaries than the amount of α-mangostin itself. Here, we show the self-assembly of α-mangostin molecules into water-dispersible particles without a need of any polymers/surfactants. Investigations on chemical structure, crystallinity and thermal properties of the obtained α-mangostin particles, in comparison to the conventional α-mangostin crystalline solid, confirm no formation of the new compound during the particle formation and suggest changes in intermolecular interactions among α-mangostin molecules and significantly more hydroxyl functionality positioned at the particles' surface. The ability of the water suspension of the α-mangostin to inhibit the growth of Propionibacterium acnes, the acne-causing bacteria, is similar to that of the solution of the conventional α-mangostin in 5% dimethyl sulfoxide. Moreover, at 12.7 ppm in an aqueous environment of RAW 264.7 cell culture, α-mangostin suspension exhibits five times higher anti-inflammatory activity than the conventional α-mangostin solution, with the same acceptable cytotoxicity of less than 20% cell death.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200543mangosteen extractcolloidself-assembly |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jutamad Bumrung Chanpen Chanchao Varol Intasanta Tanapat Palaga Supason Wanichwecharungruang |
spellingShingle |
Jutamad Bumrung Chanpen Chanchao Varol Intasanta Tanapat Palaga Supason Wanichwecharungruang Water-dispersible unadulterated α-mangostin particles for biomedical applications Royal Society Open Science mangosteen extract colloid self-assembly |
author_facet |
Jutamad Bumrung Chanpen Chanchao Varol Intasanta Tanapat Palaga Supason Wanichwecharungruang |
author_sort |
Jutamad Bumrung |
title |
Water-dispersible unadulterated α-mangostin particles for biomedical applications |
title_short |
Water-dispersible unadulterated α-mangostin particles for biomedical applications |
title_full |
Water-dispersible unadulterated α-mangostin particles for biomedical applications |
title_fullStr |
Water-dispersible unadulterated α-mangostin particles for biomedical applications |
title_full_unstemmed |
Water-dispersible unadulterated α-mangostin particles for biomedical applications |
title_sort |
water-dispersible unadulterated α-mangostin particles for biomedical applications |
publisher |
The Royal Society |
series |
Royal Society Open Science |
issn |
2054-5703 |
publishDate |
2020-11-01 |
description |
α-Mangostin, the extract from pericarp of Garcinia mangostana L. or mangosteen fruit, has been applied in various biomedical products because of its minimal skin irritation, and prominent anti-inflammatory, antimicrobial and immune-modulating activities. Owing to its low water solubility, the particle formulations are necessary for the applications of α-mangostin in aqueous media. The particle formulations are usually prepared using surfactants and/or polymers, usually at a larger amount of these auxiliaries than the amount of α-mangostin itself. Here, we show the self-assembly of α-mangostin molecules into water-dispersible particles without a need of any polymers/surfactants. Investigations on chemical structure, crystallinity and thermal properties of the obtained α-mangostin particles, in comparison to the conventional α-mangostin crystalline solid, confirm no formation of the new compound during the particle formation and suggest changes in intermolecular interactions among α-mangostin molecules and significantly more hydroxyl functionality positioned at the particles' surface. The ability of the water suspension of the α-mangostin to inhibit the growth of Propionibacterium acnes, the acne-causing bacteria, is similar to that of the solution of the conventional α-mangostin in 5% dimethyl sulfoxide. Moreover, at 12.7 ppm in an aqueous environment of RAW 264.7 cell culture, α-mangostin suspension exhibits five times higher anti-inflammatory activity than the conventional α-mangostin solution, with the same acceptable cytotoxicity of less than 20% cell death. |
topic |
mangosteen extract colloid self-assembly |
url |
https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.200543 |
work_keys_str_mv |
AT jutamadbumrung waterdispersibleunadulteratedamangostinparticlesforbiomedicalapplications AT chanpenchanchao waterdispersibleunadulteratedamangostinparticlesforbiomedicalapplications AT varolintasanta waterdispersibleunadulteratedamangostinparticlesforbiomedicalapplications AT tanapatpalaga waterdispersibleunadulteratedamangostinparticlesforbiomedicalapplications AT supasonwanichwecharungruang waterdispersibleunadulteratedamangostinparticlesforbiomedicalapplications |
_version_ |
1724336687642836992 |