Hereditary tyrosinemia type 1 in children

• Main Authors: G. V. Volynets, A. V. Nikitin, T. A. Skvortsova
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2019-11-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: children; hereditary tyrosinemia; diagnostics; treatment; clinical observations
• Online Access: https://www.ped-perinatology.ru/jour/article/view/972

Hereditary metabolic disorders include a group of diseases (more than 400) when a defect of a particular gene changes the metabolic process leading either to the accumulation of unwanted metabolites, or to a deficiency of a substance. This group also includes hereditary tyrosinemia type 1, a severe defect of tyrosine metabolism caused by deficiency of fumarylacetoacetate hydrolase (FAH) – the last enzyme of tyrosine catabolic pathway. Tyrosinemia type 1 is an autosomal recessive disorder. This paper presents a review of literature on the current state of diagnosticis and approaches to treatment of tyrosinemia using nitisinone and a low-protein diet, as well as the analysis of clinical manifestations and laboratory diagnostics of hereditary tyrosinemia type 1 in 17 children.