Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells

Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells

The accelerated metabolism of tumor cells, inevitable for maintaining high proliferation rates, is an emerging target for tumor therapy. Increased glucose and lipid metabolism as well as mitochondrial activity have been shown in solid tumors but also in leukemic cells. As tumor cells are able to esc...

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Bibliographic Details
Main Authors: Kathrin Renner, Anton Seilbeck, Nathalie Kauer, Ines Ugele, Peter J. Siska, Christina Brummer, Christina Bruss, Sonja-Maria Decking, Matthias Fante, Astrid Schmidt, Kathrin Hammon, Katrin Singer, Sebastian Klobuch, Simone Thomas, Eva Gottfried, Katrin Peter, Marina Kreutz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
metabolism
acute myeloid leukemia
AML
diclofenac
diflunisal
metformin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01258/full

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