TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets

TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets

Transient receptor potential (TRP) ion channels are essential for normal functions and health by acting as molecular sensors and transducing various stimuli into cellular and physiological responses. Growing evidence has revealed that TRP ion channels play important roles in a wide range of human di...

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Main Authors: Nelson S. Yee, Ada S. Chan, Julian D. Yee, Rosemary K. Yee
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Scientifica
Online Access:http://dx.doi.org/10.6064/2012/415158
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spelling doaj-2a104252f8244265b5259595a4b24f0b2020-11-24T21:26:39ZengHindawi LimitedScientifica2090-908X2012-01-01201210.6064/2012/415158415158TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and TargetsNelson S. Yee0Ada S. Chan1Julian D. Yee2Rosemary K. Yee3Division of Hematology-Oncology, Department of Medicine, Penn State College of Medicine, Penn State Hershey Cancer Institute, Penn State Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033-0850, USADivision of Hematology-Oncology, Department of Medicine, Penn State College of Medicine, Penn State Hershey Cancer Institute, Penn State Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033-0850, USADivision of Hematology-Oncology, Department of Medicine, Penn State College of Medicine, Penn State Hershey Cancer Institute, Penn State Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033-0850, USAPenn State Harrisburg School of Humanities, Pennsylvania State University, Middletown, PA 17057, USATransient receptor potential (TRP) ion channels are essential for normal functions and health by acting as molecular sensors and transducing various stimuli into cellular and physiological responses. Growing evidence has revealed that TRP ion channels play important roles in a wide range of human diseases, including malignancies. In light of recent discoveries, it has been found that TRP melastatin-subfamily members, TRPM7 and TRPM8, are required for normal and cancerous development of exocrine pancreas. We are currently investigating the mechanisms which mediate the functional roles of TRPM7 and TRPM8 and attempting to develop these ion channels as clinical biomarkers and therapeutic targets for achieving the goal of personalized therapy in pancreatic cancer.http://dx.doi.org/10.6064/2012/415158
collection DOAJ
language English
format Article
sources DOAJ
author Nelson S. Yee
Ada S. Chan
Julian D. Yee
Rosemary K. Yee
spellingShingle Nelson S. Yee
Ada S. Chan
Julian D. Yee
Rosemary K. Yee
TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
Scientifica
author_facet Nelson S. Yee
Ada S. Chan
Julian D. Yee
Rosemary K. Yee
author_sort Nelson S. Yee
title TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
title_short TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
title_full TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
title_fullStr TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
title_full_unstemmed TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
title_sort trpm7 and trpm8 ion channels in pancreatic adenocarcinoma: potential roles as cancer biomarkers and targets
publisher Hindawi Limited
series Scientifica
issn 2090-908X
publishDate 2012-01-01
description Transient receptor potential (TRP) ion channels are essential for normal functions and health by acting as molecular sensors and transducing various stimuli into cellular and physiological responses. Growing evidence has revealed that TRP ion channels play important roles in a wide range of human diseases, including malignancies. In light of recent discoveries, it has been found that TRP melastatin-subfamily members, TRPM7 and TRPM8, are required for normal and cancerous development of exocrine pancreas. We are currently investigating the mechanisms which mediate the functional roles of TRPM7 and TRPM8 and attempting to develop these ion channels as clinical biomarkers and therapeutic targets for achieving the goal of personalized therapy in pancreatic cancer.
url http://dx.doi.org/10.6064/2012/415158
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AT adaschan trpm7andtrpm8ionchannelsinpancreaticadenocarcinomapotentialrolesascancerbiomarkersandtargets
AT juliandyee trpm7andtrpm8ionchannelsinpancreaticadenocarcinomapotentialrolesascancerbiomarkersandtargets
AT rosemarykyee trpm7andtrpm8ionchannelsinpancreaticadenocarcinomapotentialrolesascancerbiomarkersandtargets
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