Reactions of Polychlorinated Pyrimidines with DABCO

Reactions of Polychlorinated Pyrimidines with DABCO

The reaction of 2,4,5,6-tetrachloropyrimidine (<b>4</b>) and 4,5,6-trichloropyrimidine-2-carbonitrile (<b>1</b>) with DABCO (1 equiv.), in MeCN, at ca. 20 &#176;C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (<b>5</b>) and 4,5-dichloro-6...

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Bibliographic Details
Main Authors: Andreas S. Kalogirou, Panayiotis A. Koutentis
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molbank
Subjects:
heterocycle
piperazine
pyrimidine
dabco
Online Access:https://www.mdpi.com/1422-8599/2019/4/M1084
Description
Summary:The reaction of 2,4,5,6-tetrachloropyrimidine (<b>4</b>) and 4,5,6-trichloropyrimidine-2-carbonitrile (<b>1</b>) with DABCO (1 equiv.), in MeCN, at ca. 20 &#176;C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (<b>5</b>) and 4,5-dichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine-2-carbonitrile (<b>6</b>) in 42% and 52% yields, respectively. The new compounds were fully characterized.
ISSN:1422-8599

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