Reactions of Polychlorinated Pyrimidines with DABCO

Reactions of Polychlorinated Pyrimidines with DABCO

The reaction of 2,4,5,6-tetrachloropyrimidine (<b>4</b>) and 4,5,6-trichloropyrimidine-2-carbonitrile (<b>1</b>) with DABCO (1 equiv.), in MeCN, at ca. 20 &#176;C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (<b>5</b>) and 4,5-dichloro-6...

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Main Authors: Andreas S. Kalogirou, Panayiotis A. Koutentis
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molbank
Subjects:
heterocycle
piperazine
pyrimidine
dabco
Online Access:https://www.mdpi.com/1422-8599/2019/4/M1084
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spelling doaj-2a199fe03ba14bf4a9dd9093435cf4932020-11-25T00:39:59ZengMDPI AGMolbank1422-85992019-10-0120194M108410.3390/M1084M1084Reactions of Polychlorinated Pyrimidines with DABCOAndreas S. Kalogirou0Panayiotis A. Koutentis1Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenis Str., Engomi, P. O. Box 22006, 1516 Nicosia, CyprusDepartment of Chemistry, University of Cyprus, P. O. Box 20537, 1678 Nicosia, CyprusThe reaction of 2,4,5,6-tetrachloropyrimidine (<b>4</b>) and 4,5,6-trichloropyrimidine-2-carbonitrile (<b>1</b>) with DABCO (1 equiv.), in MeCN, at ca. 20 &#176;C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (<b>5</b>) and 4,5-dichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine-2-carbonitrile (<b>6</b>) in 42% and 52% yields, respectively. The new compounds were fully characterized.https://www.mdpi.com/1422-8599/2019/4/M1084heterocyclepiperazinepyrimidinedabco
collection DOAJ
language English
format Article
sources DOAJ
author Andreas S. Kalogirou
Panayiotis A. Koutentis
spellingShingle Andreas S. Kalogirou
Panayiotis A. Koutentis
Reactions of Polychlorinated Pyrimidines with DABCO
Molbank
heterocycle
piperazine
pyrimidine
dabco
author_facet Andreas S. Kalogirou
Panayiotis A. Koutentis
author_sort Andreas S. Kalogirou
title Reactions of Polychlorinated Pyrimidines with DABCO
title_short Reactions of Polychlorinated Pyrimidines with DABCO
title_full Reactions of Polychlorinated Pyrimidines with DABCO
title_fullStr Reactions of Polychlorinated Pyrimidines with DABCO
title_full_unstemmed Reactions of Polychlorinated Pyrimidines with DABCO
title_sort reactions of polychlorinated pyrimidines with dabco
publisher MDPI AG
series Molbank
issn 1422-8599
publishDate 2019-10-01
description The reaction of 2,4,5,6-tetrachloropyrimidine (<b>4</b>) and 4,5,6-trichloropyrimidine-2-carbonitrile (<b>1</b>) with DABCO (1 equiv.), in MeCN, at ca. 20 &#176;C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (<b>5</b>) and 4,5-dichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine-2-carbonitrile (<b>6</b>) in 42% and 52% yields, respectively. The new compounds were fully characterized.
topic heterocycle
piperazine
pyrimidine
dabco
url https://www.mdpi.com/1422-8599/2019/4/M1084
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AT panayiotisakoutentis reactionsofpolychlorinatedpyrimidineswithdabco
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