Reactions of Polychlorinated Pyrimidines with DABCO
The reaction of 2,4,5,6-tetrachloropyrimidine (<b>4</b>) and 4,5,6-trichloropyrimidine-2-carbonitrile (<b>1</b>) with DABCO (1 equiv.), in MeCN, at ca. 20 °C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (<b>5</b>) and 4,5-dichloro-6...
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doaj-2a199fe03ba14bf4a9dd9093435cf4932020-11-25T00:39:59ZengMDPI AGMolbank1422-85992019-10-0120194M108410.3390/M1084M1084Reactions of Polychlorinated Pyrimidines with DABCOAndreas S. Kalogirou0Panayiotis A. Koutentis1Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenis Str., Engomi, P. O. Box 22006, 1516 Nicosia, CyprusDepartment of Chemistry, University of Cyprus, P. O. Box 20537, 1678 Nicosia, CyprusThe reaction of 2,4,5,6-tetrachloropyrimidine (<b>4</b>) and 4,5,6-trichloropyrimidine-2-carbonitrile (<b>1</b>) with DABCO (1 equiv.), in MeCN, at ca. 20 °C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (<b>5</b>) and 4,5-dichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine-2-carbonitrile (<b>6</b>) in 42% and 52% yields, respectively. The new compounds were fully characterized.https://www.mdpi.com/1422-8599/2019/4/M1084heterocyclepiperazinepyrimidinedabco |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Andreas S. Kalogirou Panayiotis A. Koutentis |
spellingShingle |
Andreas S. Kalogirou Panayiotis A. Koutentis Reactions of Polychlorinated Pyrimidines with DABCO Molbank heterocycle piperazine pyrimidine dabco |
author_facet |
Andreas S. Kalogirou Panayiotis A. Koutentis |
author_sort |
Andreas S. Kalogirou |
title |
Reactions of Polychlorinated Pyrimidines with DABCO |
title_short |
Reactions of Polychlorinated Pyrimidines with DABCO |
title_full |
Reactions of Polychlorinated Pyrimidines with DABCO |
title_fullStr |
Reactions of Polychlorinated Pyrimidines with DABCO |
title_full_unstemmed |
Reactions of Polychlorinated Pyrimidines with DABCO |
title_sort |
reactions of polychlorinated pyrimidines with dabco |
publisher |
MDPI AG |
series |
Molbank |
issn |
1422-8599 |
publishDate |
2019-10-01 |
description |
The reaction of 2,4,5,6-tetrachloropyrimidine (<b>4</b>) and 4,5,6-trichloropyrimidine-2-carbonitrile (<b>1</b>) with DABCO (1 equiv.), in MeCN, at ca. 20 °C gives 2,4,5-trichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine (<b>5</b>) and 4,5-dichloro-6-[4-(2-chloroethyl)piperazin-1-yl]pyrimidine-2-carbonitrile (<b>6</b>) in 42% and 52% yields, respectively. The new compounds were fully characterized. |
topic |
heterocycle piperazine pyrimidine dabco |
url |
https://www.mdpi.com/1422-8599/2019/4/M1084 |
work_keys_str_mv |
AT andreasskalogirou reactionsofpolychlorinatedpyrimidineswithdabco AT panayiotisakoutentis reactionsofpolychlorinatedpyrimidineswithdabco |
_version_ |
1725292023155523584 |