Whey Protein Combined with Low Dietary Fiber Improves Lipid Profile in Subjects with Abdominal Obesity: A Randomized, Controlled Trial
Abdominal obesity is associated with elevated postprandial triglycerides (TG), an independent risk factor for cardiovascular diseases. Previous studies show that whey protein (WP) and dietary fiber may separately reduce postprandial TG. However, few studies have investigated the long-term effects of...
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doaj-2a1df2ab506940489b880ee39f2a04ac2020-11-24T20:42:54ZengMDPI AGNutrients2072-66432019-09-01119209110.3390/nu11092091nu11092091Whey Protein Combined with Low Dietary Fiber Improves Lipid Profile in Subjects with Abdominal Obesity: A Randomized, Controlled TrialElin Rakvaag0Rasmus Fuglsang-Nielsen1Knud Erik Bach Knudsen2Rikard Landberg3Astrid Johannesson Hjelholt4Esben Søndergaard5Kjeld Hermansen6Søren Gregersen7Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Animal Science, Aarhus University, 8830 Tjele, DenmarkDepartment of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, SwedenDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, DenmarkDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, 8200 Aarhus, DenmarkAbdominal obesity is associated with elevated postprandial triglycerides (TG), an independent risk factor for cardiovascular diseases. Previous studies show that whey protein (WP) and dietary fiber may separately reduce postprandial TG. However, few studies have investigated the long-term effects of WP and dietary fiber on postprandial TG. We aimed to investigate the separate and combined long-term effects of WP and dietary fiber from wheat bran on postprandial TG and markers of lipid metabolism in subjects with abdominal obesity. We conducted a 12-week, double-blind, randomized, controlled, parallel intervention study. In a 2 × 2 factorial design, 73 adults were randomized to receive 60 g/day of either WP hydrolysate or maltodextrin (MD) combined with high-fiber wheat bran products (HiFi; 30 g dietary fiber/day) or low-fiber refined wheat products (LoFi; 10 g dietary fiber/day). A high-fat meal test was conducted before and after the intervention. Sixty-five subjects were included in the final analyses. There were no differences between intervention groups in postprandial TG assessed as incremental area under the curve (iAUC). WP-LoFi had reduced postprandial TG assessed as total area under the curve (tAUC) and reduced fasting TG compared with all other groups, and reduced fasting apolipoprotein B-48 compared with MD-LoFi. There were no changes in lipoprotein lipase activity. Total cholesterol and apolipoprotein B-100 were reduced after WP intake compared with MD. Total cholesterol was increased after HiFi intake compared with LoFi. In conclusion, intake of WP in combination with low-fiber cereal products for 12 weeks had beneficial effects on postprandial TG tAUC and fasting TG, but not on postprandial TG iAUC in subjects with abdominal obesity. Combining WP with high-fiber wheat bran products did not improve lipid profile.https://www.mdpi.com/2072-6643/11/9/2091whey proteindietary fiberabdominal obesitypostprandial lipemiatriglycerides |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elin Rakvaag Rasmus Fuglsang-Nielsen Knud Erik Bach Knudsen Rikard Landberg Astrid Johannesson Hjelholt Esben Søndergaard Kjeld Hermansen Søren Gregersen |
spellingShingle |
Elin Rakvaag Rasmus Fuglsang-Nielsen Knud Erik Bach Knudsen Rikard Landberg Astrid Johannesson Hjelholt Esben Søndergaard Kjeld Hermansen Søren Gregersen Whey Protein Combined with Low Dietary Fiber Improves Lipid Profile in Subjects with Abdominal Obesity: A Randomized, Controlled Trial Nutrients whey protein dietary fiber abdominal obesity postprandial lipemia triglycerides |
author_facet |
Elin Rakvaag Rasmus Fuglsang-Nielsen Knud Erik Bach Knudsen Rikard Landberg Astrid Johannesson Hjelholt Esben Søndergaard Kjeld Hermansen Søren Gregersen |
author_sort |
Elin Rakvaag |
title |
Whey Protein Combined with Low Dietary Fiber Improves Lipid Profile in Subjects with Abdominal Obesity: A Randomized, Controlled Trial |
title_short |
Whey Protein Combined with Low Dietary Fiber Improves Lipid Profile in Subjects with Abdominal Obesity: A Randomized, Controlled Trial |
title_full |
Whey Protein Combined with Low Dietary Fiber Improves Lipid Profile in Subjects with Abdominal Obesity: A Randomized, Controlled Trial |
title_fullStr |
Whey Protein Combined with Low Dietary Fiber Improves Lipid Profile in Subjects with Abdominal Obesity: A Randomized, Controlled Trial |
title_full_unstemmed |
Whey Protein Combined with Low Dietary Fiber Improves Lipid Profile in Subjects with Abdominal Obesity: A Randomized, Controlled Trial |
title_sort |
whey protein combined with low dietary fiber improves lipid profile in subjects with abdominal obesity: a randomized, controlled trial |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2019-09-01 |
description |
Abdominal obesity is associated with elevated postprandial triglycerides (TG), an independent risk factor for cardiovascular diseases. Previous studies show that whey protein (WP) and dietary fiber may separately reduce postprandial TG. However, few studies have investigated the long-term effects of WP and dietary fiber on postprandial TG. We aimed to investigate the separate and combined long-term effects of WP and dietary fiber from wheat bran on postprandial TG and markers of lipid metabolism in subjects with abdominal obesity. We conducted a 12-week, double-blind, randomized, controlled, parallel intervention study. In a 2 × 2 factorial design, 73 adults were randomized to receive 60 g/day of either WP hydrolysate or maltodextrin (MD) combined with high-fiber wheat bran products (HiFi; 30 g dietary fiber/day) or low-fiber refined wheat products (LoFi; 10 g dietary fiber/day). A high-fat meal test was conducted before and after the intervention. Sixty-five subjects were included in the final analyses. There were no differences between intervention groups in postprandial TG assessed as incremental area under the curve (iAUC). WP-LoFi had reduced postprandial TG assessed as total area under the curve (tAUC) and reduced fasting TG compared with all other groups, and reduced fasting apolipoprotein B-48 compared with MD-LoFi. There were no changes in lipoprotein lipase activity. Total cholesterol and apolipoprotein B-100 were reduced after WP intake compared with MD. Total cholesterol was increased after HiFi intake compared with LoFi. In conclusion, intake of WP in combination with low-fiber cereal products for 12 weeks had beneficial effects on postprandial TG tAUC and fasting TG, but not on postprandial TG iAUC in subjects with abdominal obesity. Combining WP with high-fiber wheat bran products did not improve lipid profile. |
topic |
whey protein dietary fiber abdominal obesity postprandial lipemia triglycerides |
url |
https://www.mdpi.com/2072-6643/11/9/2091 |
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