Determination of Isoniazid by Fe(II)-2,2’-Bipyridine Spectrophotometry

Determination of Isoniazid by Fe(II)-2,2’-Bipyridine Spectrophotometry

In acidic media, Fe(Ш) could be reduced to Fe(Ⅱ) by isoniazid, Fe(Ⅱ) reacts with 2,2'-bipyridine to form an orange complex with a maximum absorption wavelength of 522 nm. According to this principle, the content of isoniazid can be measured indirectly by measuring the amount of Fe(Ⅱ). A new met...

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Main Authors: Tu Changqing, Wen Xinrong
Format: Article
Language:English
Published: EDP Sciences 2021-01-01
Series:E3S Web of Conferences
Online Access:https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/66/e3sconf_icgec2021_01028.pdf
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spelling doaj-2a22f51990a446659006727822e988252021-07-15T06:53:50ZengEDP SciencesE3S Web of Conferences2267-12422021-01-012900102810.1051/e3sconf/202129001028e3sconf_icgec2021_01028Determination of Isoniazid by Fe(II)-2,2’-Bipyridine SpectrophotometryTu Changqing0Wen Xinrong1School of Chemistry and Environment, Jiaying University, Meizhou, Guangdong 514015, China Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas, Jiaying UniversitySchool of Chemistry and Environment, Jiaying University, Meizhou, Guangdong 514015, China Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas, Jiaying UniversityIn acidic media, Fe(Ш) could be reduced to Fe(Ⅱ) by isoniazid, Fe(Ⅱ) reacts with 2,2'-bipyridine to form an orange complex with a maximum absorption wavelength of 522 nm. According to this principle, the content of isoniazid can be measured indirectly by measuring the amount of Fe(Ⅱ). A new method for the determination of isoniazid by Fe(Ⅱ)-2,2'-bipyridine spectrophotometry has been established. At the optimum conditions, the linear relationship is good between the mass concentration of isoniazid and absorbance of Fe(Ⅱ)-2,2'-bipyridine complex in the range of 0.0004000-0.002800 mg/mL. The linear regression equation is A=0.0251+138.04C(mg/mL), and the linear correlation coefficient is 0.9995. This method is used to determine the content of isoniazid in isoniazid tablets, and the results are similar to those obtained by pharmacopoeia method.https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/66/e3sconf_icgec2021_01028.pdf
collection DOAJ
language English
format Article
sources DOAJ
author Tu Changqing
Wen Xinrong
spellingShingle Tu Changqing
Wen Xinrong
Determination of Isoniazid by Fe(II)-2,2’-Bipyridine Spectrophotometry
E3S Web of Conferences
author_facet Tu Changqing
Wen Xinrong
author_sort Tu Changqing
title Determination of Isoniazid by Fe(II)-2,2’-Bipyridine Spectrophotometry
title_short Determination of Isoniazid by Fe(II)-2,2’-Bipyridine Spectrophotometry
title_full Determination of Isoniazid by Fe(II)-2,2’-Bipyridine Spectrophotometry
title_fullStr Determination of Isoniazid by Fe(II)-2,2’-Bipyridine Spectrophotometry
title_full_unstemmed Determination of Isoniazid by Fe(II)-2,2’-Bipyridine Spectrophotometry
title_sort determination of isoniazid by fe(ii)-2,2’-bipyridine spectrophotometry
publisher EDP Sciences
series E3S Web of Conferences
issn 2267-1242
publishDate 2021-01-01
description In acidic media, Fe(Ш) could be reduced to Fe(Ⅱ) by isoniazid, Fe(Ⅱ) reacts with 2,2'-bipyridine to form an orange complex with a maximum absorption wavelength of 522 nm. According to this principle, the content of isoniazid can be measured indirectly by measuring the amount of Fe(Ⅱ). A new method for the determination of isoniazid by Fe(Ⅱ)-2,2'-bipyridine spectrophotometry has been established. At the optimum conditions, the linear relationship is good between the mass concentration of isoniazid and absorbance of Fe(Ⅱ)-2,2'-bipyridine complex in the range of 0.0004000-0.002800 mg/mL. The linear regression equation is A=0.0251+138.04C(mg/mL), and the linear correlation coefficient is 0.9995. This method is used to determine the content of isoniazid in isoniazid tablets, and the results are similar to those obtained by pharmacopoeia method.
url https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/66/e3sconf_icgec2021_01028.pdf
work_keys_str_mv AT tuchangqing determinationofisoniazidbyfeii22bipyridinespectrophotometry
AT wenxinrong determinationofisoniazidbyfeii22bipyridinespectrophotometry
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