Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic...
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| Language: | English |
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Nature Publishing Group
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18039-x |
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doaj-2a2a4da6a7984ebfa0d0c386e1408c602021-08-29T11:39:39ZengNature Publishing GroupNature Communications2041-17232020-08-0111111310.1038/s41467-020-18039-xSenolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantationJasper Iske0Midas Seyda1Timm Heinbokel2Ryoichi Maenosono3Koichiro Minami4Yeqi Nian5Markus Quante6Christine S. Falk7Haruhito Azuma8Friederike Martin9João F. Passos10Claus U. Niemann11Tamara Tchkonia12James L. Kirkland13Abdallah Elkhal14Stefan G. Tullius15Division of Transplant Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical SchoolDivision of Transplant Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical SchoolDivision of Transplant Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical SchoolDivision of Transplant Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical SchoolDivision of Transplant Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical SchoolDivision of Transplant Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of General, Visceral and Transplant Surgery, University Hospital TübingenInstitute of Transplant Immunology, Hannover Medical SchoolDepartment of Urology, Osaka Medical CollegeDepartment of General, Visceral and Transplant Surgery, Charité BerlinRobert and Arlene Kogod Center on Aging, Mayo ClinicDepartment of Anesthesia and Perioperative Care, University of California San FranciscoRobert and Arlene Kogod Center on Aging, Mayo ClinicRobert and Arlene Kogod Center on Aging, Mayo ClinicDivision of Transplant Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical SchoolDivision of Transplant Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical SchoolOrgan transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic cells may help promote survival of aged organs.https://doi.org/10.1038/s41467-020-18039-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jasper Iske Midas Seyda Timm Heinbokel Ryoichi Maenosono Koichiro Minami Yeqi Nian Markus Quante Christine S. Falk Haruhito Azuma Friederike Martin João F. Passos Claus U. Niemann Tamara Tchkonia James L. Kirkland Abdallah Elkhal Stefan G. Tullius |
| spellingShingle |
Jasper Iske Midas Seyda Timm Heinbokel Ryoichi Maenosono Koichiro Minami Yeqi Nian Markus Quante Christine S. Falk Haruhito Azuma Friederike Martin João F. Passos Claus U. Niemann Tamara Tchkonia James L. Kirkland Abdallah Elkhal Stefan G. Tullius Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation Nature Communications |
| author_facet |
Jasper Iske Midas Seyda Timm Heinbokel Ryoichi Maenosono Koichiro Minami Yeqi Nian Markus Quante Christine S. Falk Haruhito Azuma Friederike Martin João F. Passos Claus U. Niemann Tamara Tchkonia James L. Kirkland Abdallah Elkhal Stefan G. Tullius |
| author_sort |
Jasper Iske |
| title |
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation |
| title_short |
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation |
| title_full |
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation |
| title_fullStr |
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation |
| title_full_unstemmed |
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation |
| title_sort |
senolytics prevent mt-dna-induced inflammation and promote the survival of aged organs following transplantation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-08-01 |
| description |
Organ transplantation involving aged donors is often confounded by reduced post-transplantation organ survival. By studying both human organs and mouse transplantation models, here the authors show that pretreating the donors with senolytics to reduce mitochondria DNA and pro-inflammatory dendritic cells may help promote survival of aged organs. |
| url |
https://doi.org/10.1038/s41467-020-18039-x |
| work_keys_str_mv |
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