The potential of Endophytic Fungal Extract Isolated from Cinnamon (Cinnamomum burmannii) as Antidiabetic and Antioxidant
An increase in blood glucose levels in people with diabetes can cause an increase in free radicals, which can worsen the disease. Thus, drugs that have antidiabetic and antioxidant activities are needed. The cinnamon plant is high in antioxidants and has long been used as a source for a diabetes dru...
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Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University
2019-11-01
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doaj-2a3154217f48406a8d8e943391c3fecf2020-11-25T02:37:38ZengChemistry Department, Faculty of Sciences and Mathematics, Diponegoro UniversityJurnal Kimia Sains dan Aplikasi1410-89172597-99142019-11-0122627528210.14710/jksa.22.6.275-28215786The potential of Endophytic Fungal Extract Isolated from Cinnamon (Cinnamomum burmannii) as Antidiabetic and AntioxidantEris Septiana0Fauzy Rachman1Yatri Hapsari2Yadi Yadi3Bustanussalam Bustanussalam4Siti Irma Rahmawati5Fauzia Nurul izzati6Partomuan Simanjuntak7Biotechnology Research Center, Indonesian Institute of Sciences BogorBiotechnology Research Center, Indonesian Institute of Sciences BogorBiotechnology Research Center, Indonesian Institute of Sciences BogorBiotechnology Research Center, Indonesian Institute of Sciences BogorBiotechnology Research Center, Indonesian Institute of Sciences BogorBiotechnology Research Center, Indonesian Institute of Sciences BogorBiotechnology Research Center, Indonesian Institute of Sciences BogorBiotechnology Research Center, Indonesian Institute of Sciences BogorAn increase in blood glucose levels in people with diabetes can cause an increase in free radicals, which can worsen the disease. Thus, drugs that have antidiabetic and antioxidant activities are needed. The cinnamon plant is high in antioxidants and has long been used as a source for a diabetes drug. The utilization of endophytic fungi isolated from cinnamon plants as antidiabetic and antioxidant has never been reported. This study aims to investigate the antidiabetic as well as antioxidant activity from the extract of endophytic fungi from the cinnamon plant. The antidiabetic activity was tested using the α-glucosidase enzyme inhibition method, while antioxidant activity was tested using the DPPH free radical scavenging method. Total phenol content was measured based on the Follin-Ciocalteu reagent reaction. All endophytic fungal extracts from the cinnamon leaves, twigs, flowers, and fruit have antidiabetic and antioxidant activity as well as high total phenol content. The three parameters measured showed a positive correlation. Endophytic fungal extract of Cb.D6 isolate derived from the leaf had the highest antidiabetic and antioxidant activity among the other isolates amounting to 92.41% and 90.28%, respectively. In addition, the total phenol content of Cb.D6 isolates was also the highest with 357.83 mg equivalent to gallic acid/g extract. Therefore, the endophytic fungal extract of Cb.D6 isolate has the potential to be developed as a source of the antidiabetic and antioxidant ingredients.https://ejournal.undip.ac.id/index.php/ksa/article/view/24931endophytic funguscinnamonantidiabeticantioxidanttotal phenol content |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eris Septiana Fauzy Rachman Yatri Hapsari Yadi Yadi Bustanussalam Bustanussalam Siti Irma Rahmawati Fauzia Nurul izzati Partomuan Simanjuntak |
spellingShingle |
Eris Septiana Fauzy Rachman Yatri Hapsari Yadi Yadi Bustanussalam Bustanussalam Siti Irma Rahmawati Fauzia Nurul izzati Partomuan Simanjuntak The potential of Endophytic Fungal Extract Isolated from Cinnamon (Cinnamomum burmannii) as Antidiabetic and Antioxidant Jurnal Kimia Sains dan Aplikasi endophytic fungus cinnamon antidiabetic antioxidant total phenol content |
author_facet |
Eris Septiana Fauzy Rachman Yatri Hapsari Yadi Yadi Bustanussalam Bustanussalam Siti Irma Rahmawati Fauzia Nurul izzati Partomuan Simanjuntak |
author_sort |
Eris Septiana |
title |
The potential of Endophytic Fungal Extract Isolated from Cinnamon (Cinnamomum burmannii) as Antidiabetic and Antioxidant |
title_short |
The potential of Endophytic Fungal Extract Isolated from Cinnamon (Cinnamomum burmannii) as Antidiabetic and Antioxidant |
title_full |
The potential of Endophytic Fungal Extract Isolated from Cinnamon (Cinnamomum burmannii) as Antidiabetic and Antioxidant |
title_fullStr |
The potential of Endophytic Fungal Extract Isolated from Cinnamon (Cinnamomum burmannii) as Antidiabetic and Antioxidant |
title_full_unstemmed |
The potential of Endophytic Fungal Extract Isolated from Cinnamon (Cinnamomum burmannii) as Antidiabetic and Antioxidant |
title_sort |
potential of endophytic fungal extract isolated from cinnamon (cinnamomum burmannii) as antidiabetic and antioxidant |
publisher |
Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University |
series |
Jurnal Kimia Sains dan Aplikasi |
issn |
1410-8917 2597-9914 |
publishDate |
2019-11-01 |
description |
An increase in blood glucose levels in people with diabetes can cause an increase in free radicals, which can worsen the disease. Thus, drugs that have antidiabetic and antioxidant activities are needed. The cinnamon plant is high in antioxidants and has long been used as a source for a diabetes drug. The utilization of endophytic fungi isolated from cinnamon plants as antidiabetic and antioxidant has never been reported. This study aims to investigate the antidiabetic as well as antioxidant activity from the extract of endophytic fungi from the cinnamon plant. The antidiabetic activity was tested using the α-glucosidase enzyme inhibition method, while antioxidant activity was tested using the DPPH free radical scavenging method. Total phenol content was measured based on the Follin-Ciocalteu reagent reaction. All endophytic fungal extracts from the cinnamon leaves, twigs, flowers, and fruit have antidiabetic and antioxidant activity as well as high total phenol content. The three parameters measured showed a positive correlation. Endophytic fungal extract of Cb.D6 isolate derived from the leaf had the highest antidiabetic and antioxidant activity among the other isolates amounting to 92.41% and 90.28%, respectively. In addition, the total phenol content of Cb.D6 isolates was also the highest with 357.83 mg equivalent to gallic acid/g extract. Therefore, the endophytic fungal extract of Cb.D6 isolate has the potential to be developed as a source of the antidiabetic and antioxidant ingredients. |
topic |
endophytic fungus cinnamon antidiabetic antioxidant total phenol content |
url |
https://ejournal.undip.ac.id/index.php/ksa/article/view/24931 |
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