Anthrax lethal factor as an immune target in humans and transgenic mice and the impact of HLA polymorphism on CD4+ T cell immunity.
Bacillus anthracis produces a binary toxin composed of protective antigen (PA) and one of two subunits, lethal factor (LF) or edema factor (EF). Most studies have concentrated on induction of toxin-specific antibodies as the correlate of protective immunity, in contrast to which understanding of cel...
Main Authors: | Stephanie Ascough, Rebecca J Ingram, Karen K Chu, Catherine J Reynolds, Julie A Musson, Mehmet Doganay, Gökhan Metan, Yusuf Ozkul, Les Baillie, Shiranee Sriskandan, Stephen J Moore, Theresa B Gallagher, Hugh Dyson, E Diane Williamson, John H Robinson, Bernard Maillere, Rosemary J Boyton, Daniel M Altmann |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-05-01
|
Series: | PLoS Pathogens |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24788397/?tool=EBI |
Similar Items
-
Anthrax Lethal Toxin and the Induction of CD4 T Cell Immunity
by: Daniel M. Altmann, et al.
Published: (2012-10-01) -
Analysis of the CD4+ T cell immune response to Anthrax Lethal Factor
by: Ascough, Stephanie
Published: (2012) -
A review of cutaneous anthrax and its outcome
by: Mehmet Doganay, et al.
Published: (2010-09-01) -
CD4+ T cells targeting dominant and cryptic epitopes from Bacillus anthracis Lethal Factor
by: Stephanie eAscough, et al.
Published: (2016-01-01) -
Immunization of Mice with Anthrax Protective Antigen Limits Cardiotoxicity but Not Hepatotoxicity Following Lethal Toxin Challenge
by: T. Scott Devera, et al.
Published: (2015-06-01)