Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals
Background/Aim It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types of intestinal flora remains to be clarified. We aimed to analyze the associations between food intake and intestinal flora i...
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doaj-2a36b3aaa867434593c2d938a50d50532021-08-10T05:12:11ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482021-05-0136356858310.3904/kjim.2019.373170509Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individualsWeitao Shen0Jiayu Sun1Zhiyang Li2Fen Yao3Kaihuang Lin4Xiaoyang Jiao5 The Second Affiliated Hospital of Shantou University Medical College, Shantou, China Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, China The Second Affiliated Hospital of Shantou University Medical College, Shantou, China Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, China The Second Affiliated Hospital of Shantou University Medical College, Shantou, China Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, ChinaBackground/Aim It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types of intestinal flora remains to be clarified. We aimed to analyze the associations between food intake and intestinal flora in healthy and CRC individuals. Methods Food intake data were recorded using the Food Frequency Questionnaire (FFQ). The composition and diversity of the intestinal flora detected by 16S rRNA gene sequencing, and the data were analyzed by R version 3.1.1 software. Results Higher intake of red meat or pickled foods, and lower intake of white meat, fruits, vegetables, beans, nuts were found in the CRC group compared with the healthy group. Higher levels of Fusobacteria and Proteobacteria, and lower levels of Firmicutes were observed in the CRC group. Partial correlation analysis revealed that the intake of fruits, beans, and nuts was negatively correlated with Proteobacteria and Fusobacteria, but pickled food was positively correlated with Fusobacteria (p < 0.05). Fish, beans, and nuts intake was negatively correlated with Escherichia (p = 0.01). Multiple regression analysis revealed that vegetable oil (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.13 to 0.82), vegetables (OR, 0.26; 95% CI, 0.10 to 0.64), eggs (OR, 0.26; 95% CI, 0.10 to 0.69), pickled foods (OR, 21.02; 95% CI, 6.02 to 73.45), and red meat (OR, 4.23; 95% CI, 1.68 to 10.60) had an impact on CRC risk. Conclusions The species and abundance of intestinal flora varies between CRC and healthy individuals and may be affected by their food preference.http://www.kjim.org/upload/pdf/kjim-2019-373.pdfcolorectal cancerquestionnairedietary patterngastrointestinal microbiome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Weitao Shen Jiayu Sun Zhiyang Li Fen Yao Kaihuang Lin Xiaoyang Jiao |
spellingShingle |
Weitao Shen Jiayu Sun Zhiyang Li Fen Yao Kaihuang Lin Xiaoyang Jiao Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals The Korean Journal of Internal Medicine colorectal cancer questionnaire dietary pattern gastrointestinal microbiome |
author_facet |
Weitao Shen Jiayu Sun Zhiyang Li Fen Yao Kaihuang Lin Xiaoyang Jiao |
author_sort |
Weitao Shen |
title |
Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals |
title_short |
Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals |
title_full |
Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals |
title_fullStr |
Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals |
title_full_unstemmed |
Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals |
title_sort |
food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals |
publisher |
The Korean Association of Internal Medicine |
series |
The Korean Journal of Internal Medicine |
issn |
1226-3303 2005-6648 |
publishDate |
2021-05-01 |
description |
Background/Aim It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types of intestinal flora remains to be clarified. We aimed to analyze the associations between food intake and intestinal flora in healthy and CRC individuals. Methods Food intake data were recorded using the Food Frequency Questionnaire (FFQ). The composition and diversity of the intestinal flora detected by 16S rRNA gene sequencing, and the data were analyzed by R version 3.1.1 software. Results Higher intake of red meat or pickled foods, and lower intake of white meat, fruits, vegetables, beans, nuts were found in the CRC group compared with the healthy group. Higher levels of Fusobacteria and Proteobacteria, and lower levels of Firmicutes were observed in the CRC group. Partial correlation analysis revealed that the intake of fruits, beans, and nuts was negatively correlated with Proteobacteria and Fusobacteria, but pickled food was positively correlated with Fusobacteria (p < 0.05). Fish, beans, and nuts intake was negatively correlated with Escherichia (p = 0.01). Multiple regression analysis revealed that vegetable oil (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.13 to 0.82), vegetables (OR, 0.26; 95% CI, 0.10 to 0.64), eggs (OR, 0.26; 95% CI, 0.10 to 0.69), pickled foods (OR, 21.02; 95% CI, 6.02 to 73.45), and red meat (OR, 4.23; 95% CI, 1.68 to 10.60) had an impact on CRC risk. Conclusions The species and abundance of intestinal flora varies between CRC and healthy individuals and may be affected by their food preference. |
topic |
colorectal cancer questionnaire dietary pattern gastrointestinal microbiome |
url |
http://www.kjim.org/upload/pdf/kjim-2019-373.pdf |
work_keys_str_mv |
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