Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study
Abstract Background In patients with chronic kidney disease, metabolic syndrome has been demonstrated to be the culprit behind diverse complications. Adiponectin is known to have anti-atherogenic and cardio-protective effects. Meanwhile, the relationship between adiponectin and metabolic syndrome in...
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doaj-2a45f65b83df45ada0bacd760a56b6902020-11-25T01:13:32ZengBMCDiabetology & Metabolic Syndrome1758-59962016-11-018111010.1186/s13098-016-0191-zHypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD studyChang-Yun Yoon0Yung Ly Kim1Seung Hyeok Han2Tae-Hyun Yoo3Su-Ah Sung4Woo-kyung Chung5Dong-Wan Chae6Yong-Soo Kim7Curie Ahn8Kyu Hun Choi9Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei UniversityDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei UniversityDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei UniversityDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei UniversityDepartment of Internal Medicine, Eulji General HospitalDepartment of Internal Medicine, Gachon University School of MedicineDepartment of Internal Medicine, Seoul National University Bundang HospitalDepartment of Internal Medicine, Seoul St. Mary Hospital, Catholic University of KoreaDepartment of Internal Medicine, Seoul National University HospitalDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei UniversityAbstract Background In patients with chronic kidney disease, metabolic syndrome has been demonstrated to be the culprit behind diverse complications. Adiponectin is known to have anti-atherogenic and cardio-protective effects. Meanwhile, the relationship between adiponectin and metabolic syndrome in patients with chronic kidney disease has not been clarified. The aim of this study was to elucidate the relationship between adiponectin level and metabolic syndrome in patients with chronic kidney disease. Methods The KoreaN Cohort Study for Outcome in Patients with Chronic Kidney Disease is a cohort study that enrolled subjects with chronic kidney disease throughout South Korea. From February 2011 to July 2014, data were collected from 1332 patients with chronic kidney disease. Results The mean age of the patients was 53.5 years and 803 patients (60.7%) were men. The median adiponectin level was 10.7 μg/mL and 585 (44.3%) patients had metabolic syndrome. In multiple linear regression analysis, log adiponectin was positively associated with high-density lipoprotein cholesterol levels (β = 0.006), whereas it was negatively associated with serum albumin (β = −0.284), triglyceride (log β = −0.288), high sensitivity C-reactive protein (log β = −0.058) levels and estimated glomerular filtration rate (β = −0.005). Multiple logistic regression analysis indicated that low adiponectin level was independently associated with a higher risk of metabolic syndrome (per 1 μg/mL increase; odds ratio = 0.953, 95% confidence interval = 0.898–0.970, P < 0.001) after adjustment for multiple confounding factors. Conclusions Hypoadiponectinemia is independently associated with the presence of metabolic syndrome in patients with chronic kidney disease.http://link.springer.com/article/10.1186/s13098-016-0191-zAdiponectinChronic kidney diseaseMetabolic syndrome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chang-Yun Yoon Yung Ly Kim Seung Hyeok Han Tae-Hyun Yoo Su-Ah Sung Woo-kyung Chung Dong-Wan Chae Yong-Soo Kim Curie Ahn Kyu Hun Choi |
spellingShingle |
Chang-Yun Yoon Yung Ly Kim Seung Hyeok Han Tae-Hyun Yoo Su-Ah Sung Woo-kyung Chung Dong-Wan Chae Yong-Soo Kim Curie Ahn Kyu Hun Choi Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study Diabetology & Metabolic Syndrome Adiponectin Chronic kidney disease Metabolic syndrome |
author_facet |
Chang-Yun Yoon Yung Ly Kim Seung Hyeok Han Tae-Hyun Yoo Su-Ah Sung Woo-kyung Chung Dong-Wan Chae Yong-Soo Kim Curie Ahn Kyu Hun Choi |
author_sort |
Chang-Yun Yoon |
title |
Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study |
title_short |
Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study |
title_full |
Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study |
title_fullStr |
Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study |
title_full_unstemmed |
Hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the KNOW-CKD study |
title_sort |
hypoadiponectinemia and the presence of metabolic syndrome in patients with chronic kidney disease: results from the know-ckd study |
publisher |
BMC |
series |
Diabetology & Metabolic Syndrome |
issn |
1758-5996 |
publishDate |
2016-11-01 |
description |
Abstract Background In patients with chronic kidney disease, metabolic syndrome has been demonstrated to be the culprit behind diverse complications. Adiponectin is known to have anti-atherogenic and cardio-protective effects. Meanwhile, the relationship between adiponectin and metabolic syndrome in patients with chronic kidney disease has not been clarified. The aim of this study was to elucidate the relationship between adiponectin level and metabolic syndrome in patients with chronic kidney disease. Methods The KoreaN Cohort Study for Outcome in Patients with Chronic Kidney Disease is a cohort study that enrolled subjects with chronic kidney disease throughout South Korea. From February 2011 to July 2014, data were collected from 1332 patients with chronic kidney disease. Results The mean age of the patients was 53.5 years and 803 patients (60.7%) were men. The median adiponectin level was 10.7 μg/mL and 585 (44.3%) patients had metabolic syndrome. In multiple linear regression analysis, log adiponectin was positively associated with high-density lipoprotein cholesterol levels (β = 0.006), whereas it was negatively associated with serum albumin (β = −0.284), triglyceride (log β = −0.288), high sensitivity C-reactive protein (log β = −0.058) levels and estimated glomerular filtration rate (β = −0.005). Multiple logistic regression analysis indicated that low adiponectin level was independently associated with a higher risk of metabolic syndrome (per 1 μg/mL increase; odds ratio = 0.953, 95% confidence interval = 0.898–0.970, P < 0.001) after adjustment for multiple confounding factors. Conclusions Hypoadiponectinemia is independently associated with the presence of metabolic syndrome in patients with chronic kidney disease. |
topic |
Adiponectin Chronic kidney disease Metabolic syndrome |
url |
http://link.springer.com/article/10.1186/s13098-016-0191-z |
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