The Interaction between Coffee: Caffeine Consumption, UCP2 Gene Variation, and Adiposity in Adults—A Cross-Sectional Study
Background. Coffee is suggested as an alternative option for weight loss but the relationship between coffee consumption and adiposity in population-based studies is still controversial. Therefore, this study was aimed at evaluating the relationship between coffee intake and adiposity in adults and...
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doaj-2a5122f4b7264deb82634128268a78932020-11-25T01:21:11ZengHindawi LimitedJournal of Nutrition and Metabolism2090-07242090-07322019-01-01201910.1155/2019/96060549606054The Interaction between Coffee: Caffeine Consumption, UCP2 Gene Variation, and Adiposity in Adults—A Cross-Sectional StudyHarry Freitag Luglio Muhammad0Dian Caturini Sulistyoningrum1Emy Huriyati2Yi Yi Lee3Wan Abdul Manan Wan Muda4Department of Nutrition and Health, Faculty of Medicine, Public Health, Nursing, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaDepartment of Nutrition and Health, Faculty of Medicine, Public Health, Nursing, Universitas Gadjah Mada, Yogyakarta 55281, IndonesiaUnited Nation University, Kuala Lumpur 16150, MalaysiaUnited Nation University, Kuala Lumpur 16150, MalaysiaKyoto University, Kyoto 606-8501, JapanBackground. Coffee is suggested as an alternative option for weight loss but the relationship between coffee consumption and adiposity in population-based studies is still controversial. Therefore, this study was aimed at evaluating the relationship between coffee intake and adiposity in adults and to test whether uncoupling protein 2 (UCP2) gene variation was able to affect this relationship. Methods. This was a cross-sectional study conducted in male and female adults living in the urban area of Yogyakarta, Indonesia. Adiposity was determined based on body weight, body mass index (BMI), percent body fat, and waist and hip circumference. Data on coffee consumption and other dietary components were collected using a semiquantitative food frequency questionnaire along with other caffeine-containing beverages such as tea, chocolate, and other beverages. The −866 G/A UCP2 gene variation was analyzed using polymerase chain reaction-restriction fragment length polymorphism. The correlation between coffee intake and adiposity was tested using linear regression test with adjustment for sex, age, energy intake, table sugar intake, and total caffeine intake. Results. In all subjects, coffee intake was inversely correlated with body weight (β = −0.122, p=0.028), BMI (β = −0.157, p=0.005), and body fat (β = −0.135, p=0.009). In subjects with AA + GA genotypes, coffee intake was inversely correlated with body weight (β = −0.155, p=0.027), BMI (β = −0.179, p=0.010), and body fat (β = −0.148, p=0.021). By contrast, in subjects with GG genotype, coffee intake was not correlated with body weight (β = −0.017, p=0.822), BMI (β = −0.068, p=0.377), and body fat (β = −0.047, p=0.504). Conclusion. We showed that coffee intake was negatively correlated with adiposity, and this was independent of total caffeine intake. Additionally, we showed that the −866 G/A UCP2 gene variation influences the relationship between coffee intake and adiposity.http://dx.doi.org/10.1155/2019/9606054 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Harry Freitag Luglio Muhammad Dian Caturini Sulistyoningrum Emy Huriyati Yi Yi Lee Wan Abdul Manan Wan Muda |
spellingShingle |
Harry Freitag Luglio Muhammad Dian Caturini Sulistyoningrum Emy Huriyati Yi Yi Lee Wan Abdul Manan Wan Muda The Interaction between Coffee: Caffeine Consumption, UCP2 Gene Variation, and Adiposity in Adults—A Cross-Sectional Study Journal of Nutrition and Metabolism |
author_facet |
Harry Freitag Luglio Muhammad Dian Caturini Sulistyoningrum Emy Huriyati Yi Yi Lee Wan Abdul Manan Wan Muda |
author_sort |
Harry Freitag Luglio Muhammad |
title |
The Interaction between Coffee: Caffeine Consumption, UCP2 Gene Variation, and Adiposity in Adults—A Cross-Sectional Study |
title_short |
The Interaction between Coffee: Caffeine Consumption, UCP2 Gene Variation, and Adiposity in Adults—A Cross-Sectional Study |
title_full |
The Interaction between Coffee: Caffeine Consumption, UCP2 Gene Variation, and Adiposity in Adults—A Cross-Sectional Study |
title_fullStr |
The Interaction between Coffee: Caffeine Consumption, UCP2 Gene Variation, and Adiposity in Adults—A Cross-Sectional Study |
title_full_unstemmed |
The Interaction between Coffee: Caffeine Consumption, UCP2 Gene Variation, and Adiposity in Adults—A Cross-Sectional Study |
title_sort |
interaction between coffee: caffeine consumption, ucp2 gene variation, and adiposity in adults—a cross-sectional study |
publisher |
Hindawi Limited |
series |
Journal of Nutrition and Metabolism |
issn |
2090-0724 2090-0732 |
publishDate |
2019-01-01 |
description |
Background. Coffee is suggested as an alternative option for weight loss but the relationship between coffee consumption and adiposity in population-based studies is still controversial. Therefore, this study was aimed at evaluating the relationship between coffee intake and adiposity in adults and to test whether uncoupling protein 2 (UCP2) gene variation was able to affect this relationship. Methods. This was a cross-sectional study conducted in male and female adults living in the urban area of Yogyakarta, Indonesia. Adiposity was determined based on body weight, body mass index (BMI), percent body fat, and waist and hip circumference. Data on coffee consumption and other dietary components were collected using a semiquantitative food frequency questionnaire along with other caffeine-containing beverages such as tea, chocolate, and other beverages. The −866 G/A UCP2 gene variation was analyzed using polymerase chain reaction-restriction fragment length polymorphism. The correlation between coffee intake and adiposity was tested using linear regression test with adjustment for sex, age, energy intake, table sugar intake, and total caffeine intake. Results. In all subjects, coffee intake was inversely correlated with body weight (β = −0.122, p=0.028), BMI (β = −0.157, p=0.005), and body fat (β = −0.135, p=0.009). In subjects with AA + GA genotypes, coffee intake was inversely correlated with body weight (β = −0.155, p=0.027), BMI (β = −0.179, p=0.010), and body fat (β = −0.148, p=0.021). By contrast, in subjects with GG genotype, coffee intake was not correlated with body weight (β = −0.017, p=0.822), BMI (β = −0.068, p=0.377), and body fat (β = −0.047, p=0.504). Conclusion. We showed that coffee intake was negatively correlated with adiposity, and this was independent of total caffeine intake. Additionally, we showed that the −866 G/A UCP2 gene variation influences the relationship between coffee intake and adiposity. |
url |
http://dx.doi.org/10.1155/2019/9606054 |
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