The Role of Semaphorins in Metabolic Disorders
Semaphorins are a family originally identified as axonal guidance molecules. They are also involved in tumor growth, angiogenesis, immune regulation, as well as other biological and pathological processes. Recent studies have shown that semaphorins play a role in metabolic diseases including obesity...
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/16/5641 |
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doaj-2a54f49e15df4beebf86543fff25692d2020-11-25T03:33:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-01215641564110.3390/ijms21165641The Role of Semaphorins in Metabolic DisordersQiongyu Lu0Li Zhu1Cyrus Tang Hematology Center, Suzhou Key Laboratory of Thrombosis and Vascular Diseases, Soochow University, Suzhou 215123, ChinaCyrus Tang Hematology Center, Suzhou Key Laboratory of Thrombosis and Vascular Diseases, Soochow University, Suzhou 215123, ChinaSemaphorins are a family originally identified as axonal guidance molecules. They are also involved in tumor growth, angiogenesis, immune regulation, as well as other biological and pathological processes. Recent studies have shown that semaphorins play a role in metabolic diseases including obesity, adipose inflammation, and diabetic complications, including diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, diabetic wound healing, and diabetic osteoporosis. Evidence provides mechanistic insights regarding the role of semaphorins in metabolic diseases by regulating adipogenesis, hypothalamic melanocortin circuit, immune responses, and angiogenesis. In this review, we summarize recent progress regarding the role of semaphorins in obesity, adipose inflammation, and diabetic complications.https://www.mdpi.com/1422-0067/21/16/5641semaphorinsmetabolic disordersobesitydiabetic complications |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Qiongyu Lu Li Zhu |
| spellingShingle |
Qiongyu Lu Li Zhu The Role of Semaphorins in Metabolic Disorders International Journal of Molecular Sciences semaphorins metabolic disorders obesity diabetic complications |
| author_facet |
Qiongyu Lu Li Zhu |
| author_sort |
Qiongyu Lu |
| title |
The Role of Semaphorins in Metabolic Disorders |
| title_short |
The Role of Semaphorins in Metabolic Disorders |
| title_full |
The Role of Semaphorins in Metabolic Disorders |
| title_fullStr |
The Role of Semaphorins in Metabolic Disorders |
| title_full_unstemmed |
The Role of Semaphorins in Metabolic Disorders |
| title_sort |
role of semaphorins in metabolic disorders |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1661-6596 1422-0067 |
| publishDate |
2020-08-01 |
| description |
Semaphorins are a family originally identified as axonal guidance molecules. They are also involved in tumor growth, angiogenesis, immune regulation, as well as other biological and pathological processes. Recent studies have shown that semaphorins play a role in metabolic diseases including obesity, adipose inflammation, and diabetic complications, including diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, diabetic wound healing, and diabetic osteoporosis. Evidence provides mechanistic insights regarding the role of semaphorins in metabolic diseases by regulating adipogenesis, hypothalamic melanocortin circuit, immune responses, and angiogenesis. In this review, we summarize recent progress regarding the role of semaphorins in obesity, adipose inflammation, and diabetic complications. |
| topic |
semaphorins metabolic disorders obesity diabetic complications |
| url |
https://www.mdpi.com/1422-0067/21/16/5641 |
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