Liver organoids in domestic animals: an expected promise for metabolic studies
Abstract The liver is one of the most important organs, both in terms of the different metabolic processes (energy, lipid, ferric, uric, etc.) and of its central role in the processes of detoxification of substances of food origin or noxious substances (alcohol, drugs, antibiotics, etc.). The develo...
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doaj-2a56dc9f60c94ab29f5d4b3f32ac338b2021-03-21T12:44:35ZengBMCVeterinary Research1297-97162021-03-015211710.1186/s13567-021-00916-yLiver organoids in domestic animals: an expected promise for metabolic studiesCamille Baquerre0Guillaume Montillet1Bertrand Pain2Univ Lyon, Université Lyon 1, INSERM, INRAE, Stem Cell and Brain Research Institute, U1208, USC1361Univ Lyon, Université Lyon 1, INSERM, INRAE, Stem Cell and Brain Research Institute, U1208, USC1361Univ Lyon, Université Lyon 1, INSERM, INRAE, Stem Cell and Brain Research Institute, U1208, USC1361Abstract The liver is one of the most important organs, both in terms of the different metabolic processes (energy, lipid, ferric, uric, etc.) and of its central role in the processes of detoxification of substances of food origin or noxious substances (alcohol, drugs, antibiotics, etc.). The development of a relevant model that reproduces some of the functions of this tissue has become a challenge, in particular for human medicine. Thus, in recent years, most studies aimed at producing hepatocytes in vitro with the goal of developing hepatic 3D structures have been carried out in the human model. However, the tools and protocols developed using this unique model can also be considered to address physiological questions specific to this tissue in other species, such as the pig, chicken, and duck. Different strategies are presently being considered to carry out in vitro studies of the hepatic metabolism of these agronomic species.https://doi.org/10.1186/s13567-021-00916-yLiver organoidsPluripotent stem cellsMammalsBirdsDomestic species |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Camille Baquerre Guillaume Montillet Bertrand Pain |
spellingShingle |
Camille Baquerre Guillaume Montillet Bertrand Pain Liver organoids in domestic animals: an expected promise for metabolic studies Veterinary Research Liver organoids Pluripotent stem cells Mammals Birds Domestic species |
author_facet |
Camille Baquerre Guillaume Montillet Bertrand Pain |
author_sort |
Camille Baquerre |
title |
Liver organoids in domestic animals: an expected promise for metabolic studies |
title_short |
Liver organoids in domestic animals: an expected promise for metabolic studies |
title_full |
Liver organoids in domestic animals: an expected promise for metabolic studies |
title_fullStr |
Liver organoids in domestic animals: an expected promise for metabolic studies |
title_full_unstemmed |
Liver organoids in domestic animals: an expected promise for metabolic studies |
title_sort |
liver organoids in domestic animals: an expected promise for metabolic studies |
publisher |
BMC |
series |
Veterinary Research |
issn |
1297-9716 |
publishDate |
2021-03-01 |
description |
Abstract The liver is one of the most important organs, both in terms of the different metabolic processes (energy, lipid, ferric, uric, etc.) and of its central role in the processes of detoxification of substances of food origin or noxious substances (alcohol, drugs, antibiotics, etc.). The development of a relevant model that reproduces some of the functions of this tissue has become a challenge, in particular for human medicine. Thus, in recent years, most studies aimed at producing hepatocytes in vitro with the goal of developing hepatic 3D structures have been carried out in the human model. However, the tools and protocols developed using this unique model can also be considered to address physiological questions specific to this tissue in other species, such as the pig, chicken, and duck. Different strategies are presently being considered to carry out in vitro studies of the hepatic metabolism of these agronomic species. |
topic |
Liver organoids Pluripotent stem cells Mammals Birds Domestic species |
url |
https://doi.org/10.1186/s13567-021-00916-y |
work_keys_str_mv |
AT camillebaquerre liverorganoidsindomesticanimalsanexpectedpromiseformetabolicstudies AT guillaumemontillet liverorganoidsindomesticanimalsanexpectedpromiseformetabolicstudies AT bertrandpain liverorganoidsindomesticanimalsanexpectedpromiseformetabolicstudies |
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