Changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesis
Background. CVDs are the number 1 cause of death globally: more people die annually from CVDs than from any other cause. An estimated 17.5 million people died from CVDs in 2012, representing 31% of all global deaths. Of these deaths, an estimated 7.4 million were due to coronary heart disease and 6....
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Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
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doaj-2a5dd3765607409ea34c5e394b5a554b2020-11-25T02:32:03ZrusMinistry of Health of Ukraine. Dnipropetrovsk Medical Academy Морфологія1997-96651997-96652014-12-01843742Changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesisKozlov S.V.0Mayevsky A.E.1Mіshalov V.D.2Sulayeva O.N.3State institution “Dnipropetrovsk medical academy of the Ministry of Health of Ukraine”National Pirogov Memorial Medical University, VinnytsyaP.L.Shupik National Medical Academy of Post-Graduate EducationZaporizhzhia State Medical UniversityBackground. CVDs are the number 1 cause of death globally: more people die annually from CVDs than from any other cause. An estimated 17.5 million people died from CVDs in 2012, representing 31% of all global deaths. Of these deaths, an estimated 7.4 million were due to coronary heart disease and 6.7 million were due to stroke. Over three quarters of CVD deaths take place in low- and middle-income countries. Objective. Ultrastructural analysis of mitochondria in the rat contractile cardiomyocytes during postnatal ontogenesis. Methods. As the object of the study were used neonatal rat hearts, on the 5th, 10th, 15th, 30th days of life and mature animals. Hearts were investigated by the transmission electron microscopy. Volume density and numerical density of mitochondria were estimated. The Paired Student’s t-test was applied. Results. Was conducted a comprehensive ultrastructural analysis of mitochondria contractile cardiomyocytes, which allowed us to determine changes in the qualitative and quantitative parameters of mitochondria during postnatal ontogenesis, and helps to explain the dynamics and the development of mitochondria heart muscles cells after birth. Conclusion. It was shown that from the 1st to the 5th day there was a significant increase in volume density of mitochondria, which was accompanied by the increasing complexity of the ultrastructural organization of organelles. Following 20th day of postnatal ontogenesis mitochondrial structure was approaching the definitive condition and on the 30th day was the same as the mature myocardium. Citation: Kozlov SV, Mayevsky AE, Mіshalov VD, Sulayeva ON. [Changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesis]. Morphologia. 2014;8(4):37-42. Russian. http://www.morphology.dp.ua/_pub/MORPHO-2014-08-04/14ksvepo.pdfratmyocardiummitochondriamitochondrion |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
Kozlov S.V. Mayevsky A.E. Mіshalov V.D. Sulayeva O.N. |
spellingShingle |
Kozlov S.V. Mayevsky A.E. Mіshalov V.D. Sulayeva O.N. Changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesis Морфологія rat myocardium mitochondria mitochondrion |
author_facet |
Kozlov S.V. Mayevsky A.E. Mіshalov V.D. Sulayeva O.N. |
author_sort |
Kozlov S.V. |
title |
Changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesis |
title_short |
Changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesis |
title_full |
Changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesis |
title_fullStr |
Changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesis |
title_full_unstemmed |
Changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesis |
title_sort |
changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesis |
publisher |
Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy |
series |
Морфологія |
issn |
1997-9665 1997-9665 |
publishDate |
2014-12-01 |
description |
Background. CVDs are the number 1 cause of death globally: more people die annually from CVDs than from any other cause. An estimated 17.5 million people died from CVDs in 2012, representing 31% of all global deaths. Of these deaths, an estimated 7.4 million were due to coronary heart disease and 6.7 million were due to stroke. Over three quarters of CVD deaths take place in low- and middle-income countries. Objective. Ultrastructural analysis of mitochondria in the rat contractile cardiomyocytes during postnatal ontogenesis. Methods. As the object of the study were used neonatal rat hearts, on the 5th, 10th, 15th, 30th days of life and mature animals. Hearts were investigated by the transmission electron microscopy. Volume density and numerical density of mitochondria were estimated. The Paired Student’s t-test was applied. Results. Was conducted a comprehensive ultrastructural analysis of mitochondria contractile cardiomyocytes, which allowed us to determine changes in the qualitative and quantitative parameters of mitochondria during postnatal ontogenesis, and helps to explain the dynamics and the development of mitochondria heart muscles cells after birth. Conclusion. It was shown that from the 1st to the 5th day there was a significant increase in volume density of mitochondria, which was accompanied by the increasing complexity of the ultrastructural organization of organelles. Following 20th day of postnatal ontogenesis mitochondrial structure was approaching the definitive condition and on the 30th day was the same as the mature myocardium.
Citation:
Kozlov SV, Mayevsky AE, Mіshalov VD, Sulayeva ON. [Changes of mitochondria in the contractile cardiomyocytes during postnatal rat ontogenesis]. Morphologia. 2014;8(4):37-42. Russian.
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topic |
rat myocardium mitochondria mitochondrion |
url |
http://www.morphology.dp.ua/_pub/MORPHO-2014-08-04/14ksvepo.pdf |
work_keys_str_mv |
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