A Pulsatile Flow System to Engineer Aneurysm and Atherosclerosis Mimetic Extracellular Matrix

A Pulsatile Flow System to Engineer Aneurysm and Atherosclerosis Mimetic Extracellular Matrix

Abstract Alterations of blood flow patterns strongly correlate with arterial wall diseases such as atherosclerosis and aneurysm. Here, a simple, pumpless, close‐loop, easy‐to‐replicate, and miniaturized flow device is introduced to concurrently expose 3D engineered vascular smooth muscle tissues to...

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Bibliographic Details
Main Authors: Vahid Hosseini, Anna Mallone, Nima Mirkhani, Jerome Noir, Mehdi Salek, Francesco Silvio Pasqualini, Simone Schuerle, Ali Khademhosseini, Simon P. Hoerstrup, Viola Vogel
Format: Article
Language:English
Published: Wiley 2020-06-01
Series:Advanced Science
Subjects:
aneurysms
arterial wall diseases
atherosclerosis
extracellular matrix
human vascular smooth muscle cells
in vitro 3D tissue models
Online Access:https://doi.org/10.1002/advs.202000173

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