Application of mesenchymal stem cell sheet to treatment of ischemic heart disease
Abstract In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac function and attenuate adverse ventricular remodeling of the ischemic myocardium through paracrine effects and immunoregulation functions. In combination with cell sheet technology, MSCs could be more easily tr...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-07-01
|
Series: | Stem Cell Research & Therapy |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13287-021-02451-1 |
id |
doaj-2a6f8d819a044f9f80e95b0033b403ef |
---|---|
record_format |
Article |
spelling |
doaj-2a6f8d819a044f9f80e95b0033b403ef2021-07-11T11:07:12ZengBMCStem Cell Research & Therapy1757-65122021-07-0112111010.1186/s13287-021-02451-1Application of mesenchymal stem cell sheet to treatment of ischemic heart diseaseDehua Chang0Taibing Fan1Shuang Gao2Yongqiang Jin3Mingkui Zhang4Minoru Ono5Department of Cell Therapy in Regenerative Medicine, The University of Tokyo HospitalChildren Heart Center, Fuwai Central China Cardiovascular HospitalResearch and Development Department, BOE Regenerative Medicine Technology Co., Ltd.Heart Center, First Hospital of Tsinghua UniversityHeart Center, First Hospital of Tsinghua UniversityDepartment of Cardiac Surgery, The University of Tokyo HospitalAbstract In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac function and attenuate adverse ventricular remodeling of the ischemic myocardium through paracrine effects and immunoregulation functions. In combination with cell sheet technology, MSCs could be more easily transplanted to the ischemic area. The long-term retention of MSCs in the affected area was realized and significantly improved the curative effect. In this review, we summarized the research and the applications of MSC sheets to the treatment of ischemic heart tissue. At present, many types of MSCs have been considered as multipotent cells in the treatment of heart failure, such as bone marrow-derived mesenchymal stem cells (BM-MSCs), adipose-derived mesenchymal stem cells (AD-MSCs), umbilical cord-derived mesenchymal stem cells (UC-MSCs), and skeletal myoblasts (SMs). Since UC-MSCs have few human leukocyte antigen-II and major histocompatibility complex class I molecules, and are easy to isolate and culture, UC-MSC sheets have been proposed as a candidate for clinical applications to ischemic heart disease.https://doi.org/10.1186/s13287-021-02451-1Cell sheetCardiac tissueCell therapyMesenchymal stem cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dehua Chang Taibing Fan Shuang Gao Yongqiang Jin Mingkui Zhang Minoru Ono |
spellingShingle |
Dehua Chang Taibing Fan Shuang Gao Yongqiang Jin Mingkui Zhang Minoru Ono Application of mesenchymal stem cell sheet to treatment of ischemic heart disease Stem Cell Research & Therapy Cell sheet Cardiac tissue Cell therapy Mesenchymal stem cells |
author_facet |
Dehua Chang Taibing Fan Shuang Gao Yongqiang Jin Mingkui Zhang Minoru Ono |
author_sort |
Dehua Chang |
title |
Application of mesenchymal stem cell sheet to treatment of ischemic heart disease |
title_short |
Application of mesenchymal stem cell sheet to treatment of ischemic heart disease |
title_full |
Application of mesenchymal stem cell sheet to treatment of ischemic heart disease |
title_fullStr |
Application of mesenchymal stem cell sheet to treatment of ischemic heart disease |
title_full_unstemmed |
Application of mesenchymal stem cell sheet to treatment of ischemic heart disease |
title_sort |
application of mesenchymal stem cell sheet to treatment of ischemic heart disease |
publisher |
BMC |
series |
Stem Cell Research & Therapy |
issn |
1757-6512 |
publishDate |
2021-07-01 |
description |
Abstract In recent years, mesenchymal stem cells (MSCs) have been used to improve cardiac function and attenuate adverse ventricular remodeling of the ischemic myocardium through paracrine effects and immunoregulation functions. In combination with cell sheet technology, MSCs could be more easily transplanted to the ischemic area. The long-term retention of MSCs in the affected area was realized and significantly improved the curative effect. In this review, we summarized the research and the applications of MSC sheets to the treatment of ischemic heart tissue. At present, many types of MSCs have been considered as multipotent cells in the treatment of heart failure, such as bone marrow-derived mesenchymal stem cells (BM-MSCs), adipose-derived mesenchymal stem cells (AD-MSCs), umbilical cord-derived mesenchymal stem cells (UC-MSCs), and skeletal myoblasts (SMs). Since UC-MSCs have few human leukocyte antigen-II and major histocompatibility complex class I molecules, and are easy to isolate and culture, UC-MSC sheets have been proposed as a candidate for clinical applications to ischemic heart disease. |
topic |
Cell sheet Cardiac tissue Cell therapy Mesenchymal stem cells |
url |
https://doi.org/10.1186/s13287-021-02451-1 |
work_keys_str_mv |
AT dehuachang applicationofmesenchymalstemcellsheettotreatmentofischemicheartdisease AT taibingfan applicationofmesenchymalstemcellsheettotreatmentofischemicheartdisease AT shuanggao applicationofmesenchymalstemcellsheettotreatmentofischemicheartdisease AT yongqiangjin applicationofmesenchymalstemcellsheettotreatmentofischemicheartdisease AT mingkuizhang applicationofmesenchymalstemcellsheettotreatmentofischemicheartdisease AT minoruono applicationofmesenchymalstemcellsheettotreatmentofischemicheartdisease |
_version_ |
1721309311450218496 |