The Role of PPARα Activation in Liver and Muscle

The Role of PPARα Activation in Liver and Muscle

PPARα is one of three members of the soluble nuclear receptor family called peroxisome proliferator-activated receptor (PPAR). It is a sensor for changes in levels of fatty acids and their derivatives that responds to ligand binding with PPAR target gene transcription, inasmuch as it can influence p...

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Main Authors: Lena Burri, G. Hege Thoresen, Rolf K. Berge
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2010/542359
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spelling doaj-2a7698f669ad48d3995ddf43b55b8b892020-11-25T00:22:34ZengHindawi LimitedPPAR Research1687-47571687-47652010-01-01201010.1155/2010/542359542359The Role of PPARα Activation in Liver and MuscleLena Burri0G. Hege Thoresen1Rolf K. Berge2Institute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayDepartment of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, 0316 Oslo, NorwayInstitute of Medicine, Haukeland University Hospital, University of Bergen, 5021 Bergen, NorwayPPARα is one of three members of the soluble nuclear receptor family called peroxisome proliferator-activated receptor (PPAR). It is a sensor for changes in levels of fatty acids and their derivatives that responds to ligand binding with PPAR target gene transcription, inasmuch as it can influence physiological homeostasis, including lipid and carbohydrate metabolism in various tissues. In this paper we summarize the involvement of PPARα in the metabolically active tissues liver and skeletal muscle and provide an overview of the risks and benefits of ligand activation of PPARα, with particular consideration to interspecies differences.http://dx.doi.org/10.1155/2010/542359
collection DOAJ
language English
format Article
sources DOAJ
author Lena Burri
G. Hege Thoresen
Rolf K. Berge
spellingShingle Lena Burri
G. Hege Thoresen
Rolf K. Berge
The Role of PPARα Activation in Liver and Muscle
PPAR Research
author_facet Lena Burri
G. Hege Thoresen
Rolf K. Berge
author_sort Lena Burri
title The Role of PPARα Activation in Liver and Muscle
title_short The Role of PPARα Activation in Liver and Muscle
title_full The Role of PPARα Activation in Liver and Muscle
title_fullStr The Role of PPARα Activation in Liver and Muscle
title_full_unstemmed The Role of PPARα Activation in Liver and Muscle
title_sort role of pparα activation in liver and muscle
publisher Hindawi Limited
series PPAR Research
issn 1687-4757
1687-4765
publishDate 2010-01-01
description PPARα is one of three members of the soluble nuclear receptor family called peroxisome proliferator-activated receptor (PPAR). It is a sensor for changes in levels of fatty acids and their derivatives that responds to ligand binding with PPAR target gene transcription, inasmuch as it can influence physiological homeostasis, including lipid and carbohydrate metabolism in various tissues. In this paper we summarize the involvement of PPARα in the metabolically active tissues liver and skeletal muscle and provide an overview of the risks and benefits of ligand activation of PPARα, with particular consideration to interspecies differences.
url http://dx.doi.org/10.1155/2010/542359
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