Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value
Background. Endothelial-derived microparticles (EDMPs) and platelet-derived microparticles (PDMPs) have been reported to be increasing in various diseases including malignant diseases. Here, we investigated whether these MPs may be useful biomarkers for predicting lung cancer (LC) disease status, ce...
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Format: | Article |
Language: | English |
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Hindawi Limited
2013-01-01
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Series: | Disease Markers |
Online Access: | http://dx.doi.org/10.1155/2013/715472 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chia-Cheng Tseng Chin-Chou Wang Huang-Chih Chang Tzu-Hsien Tsai Li-Teh Chang Kuo-Tung Huang Steve Leu Chia-Hung Yen Shih-Feng Liu Chih-Hung Chen Cheng-Ta Yang Hon-Kan Yip Meng-Chih Lin |
spellingShingle |
Chia-Cheng Tseng Chin-Chou Wang Huang-Chih Chang Tzu-Hsien Tsai Li-Teh Chang Kuo-Tung Huang Steve Leu Chia-Hung Yen Shih-Feng Liu Chih-Hung Chen Cheng-Ta Yang Hon-Kan Yip Meng-Chih Lin Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value Disease Markers |
author_facet |
Chia-Cheng Tseng Chin-Chou Wang Huang-Chih Chang Tzu-Hsien Tsai Li-Teh Chang Kuo-Tung Huang Steve Leu Chia-Hung Yen Shih-Feng Liu Chih-Hung Chen Cheng-Ta Yang Hon-Kan Yip Meng-Chih Lin |
author_sort |
Chia-Cheng Tseng |
title |
Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value |
title_short |
Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value |
title_full |
Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value |
title_fullStr |
Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value |
title_full_unstemmed |
Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic Value |
title_sort |
levels of circulating microparticles in lung cancer patients and possible prognostic value |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2013-01-01 |
description |
Background. Endothelial-derived microparticles (EDMPs) and platelet-derived microparticles (PDMPs) have been reported to be increasing in various diseases including malignant diseases. Here, we investigated whether these MPs may be useful biomarkers for predicting lung cancer (LC) disease status, cell type, or metastasis. Methods and Results. One hundred and thirty LC patients were prospectively enrolled into the study between April 2011 and February 2012. Flow cytometric analysis demonstrated that the circulating levels of platelet-derived activated MPs (PDAc-MPs), platelet-derived apoptotic MPs (PDAp-MPs), endothelial-derived activated MPs (EDAc-MPs), and endothelial-derived apoptotic MPs (EDAp-MPs) were significantly higher in LC patients than in 30 age- and gender-matched normal control subjects (all P<0.05). Additionally, circulating level of PDAc-MPs was significantly lower (P=0.031), whereas the circulating levels of the other three biomarkers did not differ (all P>0.1) in early stage versus late stage LC patients. Furthermore, the circulating levels of the four types of MPs did not differ among patients with different disease statuses (i.e., disease controlled, disease progression, and disease without treatment, i.e., fresh case) (all P>0.2) or between patients with or without LC metastasis (all P>0.5). Moreover, only the circulating level of EDAp-MPs was significantly associated with the different cell types (i.e., squamous cell carcinoma, adenocarcinoma, and small cell carcinoma) of LC (P=0.045). Conclusion. Circulating MP levels are significantly increased in LC patients as compared with normal subjects. Among the MPs, only an increased level of EDAp-MPs was significantly associated with different LC cell types. |
url |
http://dx.doi.org/10.1155/2013/715472 |
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doaj-2a78d8849a984f0bbeb81aeb102a158d2020-11-25T00:22:34ZengHindawi LimitedDisease Markers0278-02401875-86302013-01-0135530131010.1155/2013/715472715472Levels of Circulating Microparticles in Lung Cancer Patients and Possible Prognostic ValueChia-Cheng Tseng0Chin-Chou Wang1Huang-Chih Chang2Tzu-Hsien Tsai3Li-Teh Chang4Kuo-Tung Huang5Steve Leu6Chia-Hung Yen7Shih-Feng Liu8Chih-Hung Chen9Cheng-Ta Yang10Hon-Kan Yip11Meng-Chih Lin12Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123 Ta Pei Road, Niao Sung District, Kaohsiung 83301, TaiwanBasic Science, Nursing Department, Meiho University, Pingtung 900, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanCenter for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Life Science, National Pingtung University of Science and Technology, Pingtung 900, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDivisions of General Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 123 Ta Pei Road, Niao Sung District, Kaohsiung 83301, TaiwanDepartment of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan 333, TaiwanDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123 Ta Pei Road, Niao Sung District, Kaohsiung 83301, TaiwanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanBackground. Endothelial-derived microparticles (EDMPs) and platelet-derived microparticles (PDMPs) have been reported to be increasing in various diseases including malignant diseases. Here, we investigated whether these MPs may be useful biomarkers for predicting lung cancer (LC) disease status, cell type, or metastasis. Methods and Results. One hundred and thirty LC patients were prospectively enrolled into the study between April 2011 and February 2012. Flow cytometric analysis demonstrated that the circulating levels of platelet-derived activated MPs (PDAc-MPs), platelet-derived apoptotic MPs (PDAp-MPs), endothelial-derived activated MPs (EDAc-MPs), and endothelial-derived apoptotic MPs (EDAp-MPs) were significantly higher in LC patients than in 30 age- and gender-matched normal control subjects (all P<0.05). Additionally, circulating level of PDAc-MPs was significantly lower (P=0.031), whereas the circulating levels of the other three biomarkers did not differ (all P>0.1) in early stage versus late stage LC patients. Furthermore, the circulating levels of the four types of MPs did not differ among patients with different disease statuses (i.e., disease controlled, disease progression, and disease without treatment, i.e., fresh case) (all P>0.2) or between patients with or without LC metastasis (all P>0.5). Moreover, only the circulating level of EDAp-MPs was significantly associated with the different cell types (i.e., squamous cell carcinoma, adenocarcinoma, and small cell carcinoma) of LC (P=0.045). Conclusion. Circulating MP levels are significantly increased in LC patients as compared with normal subjects. Among the MPs, only an increased level of EDAp-MPs was significantly associated with different LC cell types.http://dx.doi.org/10.1155/2013/715472 |