A model for how signal duration can determine distinct outcomes of gene transcription programs.

A model for how signal duration can determine distinct outcomes of gene transcription programs.

The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood. It is known that IL-6 induces a transient STAT3 signal and that IL-10 induces a sustained STAT3...

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Bibliographic Details
Main Authors: Kevin D Fowler, Vijay K Kuchroo, Arup K Chakraborty
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3302786?pdf=render

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