Both Stationary and Dynamic Functional Interhemispheric Connectivity Are Strongly Associated With Performance on Cognitive Tests in Multiple Sclerosis
Although functional connectivity has been extensively studied in MS, robust estimates of both stationary (static connectivity at the time) and dynamic (connectivity variation across time) functional connectivity has not been commonly evaluated and neither has its association to cognition. In this st...
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doaj-2a92ce2592c4420e97bd757ab7aede1c2020-11-25T03:52:32ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-06-011110.3389/fneur.2020.00407511001Both Stationary and Dynamic Functional Interhemispheric Connectivity Are Strongly Associated With Performance on Cognitive Tests in Multiple SclerosisSue-Jin Lin0Shannon Kolind1Aiping Liu2Katrina McMullen3Irene Vavasour4Z. Jane Wang5Anthony Traboulsee6Martin J. McKeown7Martin J. McKeown8Graduate Program in Neuroscience, University of British Columbia, Vancouver, BC, CanadaDivision of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, BC, CanadaDepartment of Electrical and Computer Engineering Program, University of British Columbia, Vancouver, BC, CanadaDivision of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, BC, CanadaDepartment of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, BC, CanadaDepartment of Electrical and Computer Engineering Program, University of British Columbia, Vancouver, BC, CanadaDivision of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, BC, CanadaGraduate Program in Neuroscience, University of British Columbia, Vancouver, BC, CanadaDivision of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, BC, CanadaAlthough functional connectivity has been extensively studied in MS, robust estimates of both stationary (static connectivity at the time) and dynamic (connectivity variation across time) functional connectivity has not been commonly evaluated and neither has its association to cognition. In this study, we focused on interhemispheric connections as previous research has shown links between anatomical homologous connections and cognition. We examined functional interhemispheric connectivity (IC) in MS during resting-state functional MRI using both stationary and dynamic strategies and related connectivity measures to processing speed performance. Twenty-five patients with relapsing-remitting MS and 41 controls were recruited. Stationary functional IC was assessed between homologous Regions of Interest (ROIs) using correlation. For dynamic IC, a sliding window approach was used to quantify changes between homologous ROIs across time. We related IC measures to cognitive performance with correlation and regression. Compared to control subjects, MS demonstrated increased IC across homologous regions, which accurately predicted performance on the symbol digit modalities test (SDMT) (R2 = 0.96) and paced auditory serial addition test (PASAT) (R2 = 0.59). Dynamic measures were not different between the 2 groups, but dynamic IC was related to PASAT scores. The associations between stationary/dynamic connectivity and cognitive tests demonstrated that different aspects of functional IC were associated with cognitive processes. Processing speed measured in SDMT was associated with static interhemispheric connections and better PASAT performance, which requires working memory, sustain attention, and processing speed, was more related to rigid IC, underlining the neurophysiological mechanism of cognition in MS.https://www.frontiersin.org/article/10.3389/fneur.2020.00407/fullstatic functional connectivitydynamic functional connectivitymultiple sclerosissymbol digit modalities testpaced auditory serial addition testresting state fMRI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sue-Jin Lin Shannon Kolind Aiping Liu Katrina McMullen Irene Vavasour Z. Jane Wang Anthony Traboulsee Martin J. McKeown Martin J. McKeown |
spellingShingle |
Sue-Jin Lin Shannon Kolind Aiping Liu Katrina McMullen Irene Vavasour Z. Jane Wang Anthony Traboulsee Martin J. McKeown Martin J. McKeown Both Stationary and Dynamic Functional Interhemispheric Connectivity Are Strongly Associated With Performance on Cognitive Tests in Multiple Sclerosis Frontiers in Neurology static functional connectivity dynamic functional connectivity multiple sclerosis symbol digit modalities test paced auditory serial addition test resting state fMRI |
author_facet |
Sue-Jin Lin Shannon Kolind Aiping Liu Katrina McMullen Irene Vavasour Z. Jane Wang Anthony Traboulsee Martin J. McKeown Martin J. McKeown |
author_sort |
Sue-Jin Lin |
title |
Both Stationary and Dynamic Functional Interhemispheric Connectivity Are Strongly Associated With Performance on Cognitive Tests in Multiple Sclerosis |
title_short |
Both Stationary and Dynamic Functional Interhemispheric Connectivity Are Strongly Associated With Performance on Cognitive Tests in Multiple Sclerosis |
title_full |
Both Stationary and Dynamic Functional Interhemispheric Connectivity Are Strongly Associated With Performance on Cognitive Tests in Multiple Sclerosis |
title_fullStr |
Both Stationary and Dynamic Functional Interhemispheric Connectivity Are Strongly Associated With Performance on Cognitive Tests in Multiple Sclerosis |
title_full_unstemmed |
Both Stationary and Dynamic Functional Interhemispheric Connectivity Are Strongly Associated With Performance on Cognitive Tests in Multiple Sclerosis |
title_sort |
both stationary and dynamic functional interhemispheric connectivity are strongly associated with performance on cognitive tests in multiple sclerosis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2020-06-01 |
description |
Although functional connectivity has been extensively studied in MS, robust estimates of both stationary (static connectivity at the time) and dynamic (connectivity variation across time) functional connectivity has not been commonly evaluated and neither has its association to cognition. In this study, we focused on interhemispheric connections as previous research has shown links between anatomical homologous connections and cognition. We examined functional interhemispheric connectivity (IC) in MS during resting-state functional MRI using both stationary and dynamic strategies and related connectivity measures to processing speed performance. Twenty-five patients with relapsing-remitting MS and 41 controls were recruited. Stationary functional IC was assessed between homologous Regions of Interest (ROIs) using correlation. For dynamic IC, a sliding window approach was used to quantify changes between homologous ROIs across time. We related IC measures to cognitive performance with correlation and regression. Compared to control subjects, MS demonstrated increased IC across homologous regions, which accurately predicted performance on the symbol digit modalities test (SDMT) (R2 = 0.96) and paced auditory serial addition test (PASAT) (R2 = 0.59). Dynamic measures were not different between the 2 groups, but dynamic IC was related to PASAT scores. The associations between stationary/dynamic connectivity and cognitive tests demonstrated that different aspects of functional IC were associated with cognitive processes. Processing speed measured in SDMT was associated with static interhemispheric connections and better PASAT performance, which requires working memory, sustain attention, and processing speed, was more related to rigid IC, underlining the neurophysiological mechanism of cognition in MS. |
topic |
static functional connectivity dynamic functional connectivity multiple sclerosis symbol digit modalities test paced auditory serial addition test resting state fMRI |
url |
https://www.frontiersin.org/article/10.3389/fneur.2020.00407/full |
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