Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study
INTRODUCTION: Male testosterone deficiency is associated with bad sexual function and quality of life (QoL). The aim of this study was to determine whether a daily dose of 25 mg clomiphene citrate (CC) is effective in stimulating the endogenous testosterone production pathway and to address the appl...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Sociedade Brasileira de Urologia
2012-08-01
|
Series: | International Brazilian Journal of Urology |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000400011 |
id |
doaj-2a96ea2f065f43ffa9c8e8be1b974c0e |
---|---|
record_format |
Article |
spelling |
doaj-2a96ea2f065f43ffa9c8e8be1b974c0e2020-11-24T23:38:48ZengSociedade Brasileira de UrologiaInternational Brazilian Journal of Urology1677-55381677-61192012-08-0138451251810.1590/S1677-55382012000400011Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective studyCarlos Teodósio Da RosMárcio Augusto AverbeckINTRODUCTION: Male testosterone deficiency is associated with bad sexual function and quality of life (QoL). The aim of this study was to determine whether a daily dose of 25 mg clomiphene citrate (CC) is effective in stimulating the endogenous testosterone production pathway and to address the applicability of this medication as a therapeutic option for symptomatic hypogonadism. MATERIALS AND METHODS: This was a prospective study. Men with low sexual desire and testosterone levels (T) below 400 ng/dL were selected to receive CC. Blood samples were obtained to determine baseline measurements of serum T, estradiol, LH, lipid profile and fasting plasma glucose. Each patient was treated with a daily dose of 25 mg CC for at least 3 months. Patients were asked if they experienced any side effects related to the use of CC and if they experienced any improvement in their sexual profile. Paired samples T-test was utilized to analyze responses to therapy. RESULTS: Our cohort consisted of 125 men with hypogonadism and low libido. Mean age was 62 years (± 11.1 years). Serum T levels ranged from 309 ng/dL (baseline, mean value) to 642 ng/dL (3 months after CC initiation, mean value) (p < 0.001). Serum cholesterol levels ranged from 197 to 186 mg/dL (p = 0.003). There were no statistically significant differences when comparing pre and post-treatment HDL-Cholesterol, triglycerides, fasting plasma glucose and prolactin. All men reported improvements in the post-treatment QoL scores. No serious adverse events were recorded. CONCLUSIONS: The CC was effective in stimulating the endogenous production of testosterone. A lower level of total cholesterol was verified after three months of treatment. This medication should be considered as a therapeutic option for some patients with symptomatic male testosterone deficiency.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000400011HypogonadismClomipheneTreatment Outcome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carlos Teodósio Da Ros Márcio Augusto Averbeck |
spellingShingle |
Carlos Teodósio Da Ros Márcio Augusto Averbeck Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study International Brazilian Journal of Urology Hypogonadism Clomiphene Treatment Outcome |
author_facet |
Carlos Teodósio Da Ros Márcio Augusto Averbeck |
author_sort |
Carlos Teodósio Da Ros |
title |
Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study |
title_short |
Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study |
title_full |
Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study |
title_fullStr |
Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study |
title_full_unstemmed |
Twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study |
title_sort |
twenty-five milligrams of clomiphene citrate presents positive effect on treatment of male testosterone deficiency - a prospective study |
publisher |
Sociedade Brasileira de Urologia |
series |
International Brazilian Journal of Urology |
issn |
1677-5538 1677-6119 |
publishDate |
2012-08-01 |
description |
INTRODUCTION: Male testosterone deficiency is associated with bad sexual function and quality of life (QoL). The aim of this study was to determine whether a daily dose of 25 mg clomiphene citrate (CC) is effective in stimulating the endogenous testosterone production pathway and to address the applicability of this medication as a therapeutic option for symptomatic hypogonadism. MATERIALS AND METHODS: This was a prospective study. Men with low sexual desire and testosterone levels (T) below 400 ng/dL were selected to receive CC. Blood samples were obtained to determine baseline measurements of serum T, estradiol, LH, lipid profile and fasting plasma glucose. Each patient was treated with a daily dose of 25 mg CC for at least 3 months. Patients were asked if they experienced any side effects related to the use of CC and if they experienced any improvement in their sexual profile. Paired samples T-test was utilized to analyze responses to therapy. RESULTS: Our cohort consisted of 125 men with hypogonadism and low libido. Mean age was 62 years (± 11.1 years). Serum T levels ranged from 309 ng/dL (baseline, mean value) to 642 ng/dL (3 months after CC initiation, mean value) (p < 0.001). Serum cholesterol levels ranged from 197 to 186 mg/dL (p = 0.003). There were no statistically significant differences when comparing pre and post-treatment HDL-Cholesterol, triglycerides, fasting plasma glucose and prolactin. All men reported improvements in the post-treatment QoL scores. No serious adverse events were recorded. CONCLUSIONS: The CC was effective in stimulating the endogenous production of testosterone. A lower level of total cholesterol was verified after three months of treatment. This medication should be considered as a therapeutic option for some patients with symptomatic male testosterone deficiency. |
topic |
Hypogonadism Clomiphene Treatment Outcome |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382012000400011 |
work_keys_str_mv |
AT carlosteodosiodaros twentyfivemilligramsofclomiphenecitratepresentspositiveeffectontreatmentofmaletestosteronedeficiencyaprospectivestudy AT marcioaugustoaverbeck twentyfivemilligramsofclomiphenecitratepresentspositiveeffectontreatmentofmaletestosteronedeficiencyaprospectivestudy |
_version_ |
1725515646571118592 |