S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes
Heart disease: A key enzyme for healthy contraction Enhancing activity of an enzyme that promotes healthy heart contraction could benefit patients at risk of serious heart conditions. Chronic high blood pressure can cause excessive thickening of heart muscle tissue, reducing the heart’s ability to c...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-04-01
|
Series: | Experimental and Molecular Medicine |
Online Access: | https://doi.org/10.1038/s12276-017-0021-x |
id |
doaj-2a97040d82204f528051758e12456f59 |
---|---|
record_format |
Article |
spelling |
doaj-2a97040d82204f528051758e12456f592020-12-08T13:51:07ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132018-04-0150411110.1038/s12276-017-0021-xS-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytesEui Man Jeong0Chun Zi Jin1Ji Hyun Jang2Zai Hao Zhao3Chun Li Jin4Jin Hang Lee5Ki Baek Lee6Sung Joon Kim7In-Gyu Kim8Yin Hua Zhang9Department of Biochemistry and Molecular Biology, Seoul National University College of MedicineDepartment of Physiology, Ischemic/Hypoxic Disease Institute, Seoul National University College of MedicineDepartment of Physiology, Ischemic/Hypoxic Disease Institute, Seoul National University College of MedicineDepartment of Physiology, Ischemic/Hypoxic Disease Institute, Seoul National University College of MedicineDepartment of Physiology, Ischemic/Hypoxic Disease Institute, Seoul National University College of MedicineDepartment of Biochemistry and Molecular Biology, Seoul National University College of MedicineDepartment of Biochemistry and Molecular Biology, Seoul National University College of MedicineDepartment of Physiology, Ischemic/Hypoxic Disease Institute, Seoul National University College of MedicineDepartment of Biochemistry and Molecular Biology, Seoul National University College of MedicineDepartment of Physiology, Ischemic/Hypoxic Disease Institute, Seoul National University College of MedicineHeart disease: A key enzyme for healthy contraction Enhancing activity of an enzyme that promotes healthy heart contraction could benefit patients at risk of serious heart conditions. Chronic high blood pressure can cause excessive thickening of heart muscle tissue, reducing the heart’s ability to contract correctly and leading to heart failure. A healthy heart fuels itself by oxidizing fatty acids to trigger production of the key energy transfer molecule ATP. Yin Hua Zhang and In-Gyu Kim at Seoul National University College of Medicine, Korea and co-workers have highlighted how S-nitrosylation, addition of nitric oxide, affects transglutaminase 2 (TG2), an enzyme that promotes ATP production. Experiments on rats and mice showed that fatty acids activate TG2, increasing ATP production and maintaining contractibility in healthy hearts. However, in pressure-overloaded hearts, TG2 activity is inhibited by S-nitrosylation, which stops heart muscle cells contracting properly.https://doi.org/10.1038/s12276-017-0021-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eui Man Jeong Chun Zi Jin Ji Hyun Jang Zai Hao Zhao Chun Li Jin Jin Hang Lee Ki Baek Lee Sung Joon Kim In-Gyu Kim Yin Hua Zhang |
spellingShingle |
Eui Man Jeong Chun Zi Jin Ji Hyun Jang Zai Hao Zhao Chun Li Jin Jin Hang Lee Ki Baek Lee Sung Joon Kim In-Gyu Kim Yin Hua Zhang S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes Experimental and Molecular Medicine |
author_facet |
Eui Man Jeong Chun Zi Jin Ji Hyun Jang Zai Hao Zhao Chun Li Jin Jin Hang Lee Ki Baek Lee Sung Joon Kim In-Gyu Kim Yin Hua Zhang |
author_sort |
Eui Man Jeong |
title |
S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes |
title_short |
S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes |
title_full |
S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes |
title_fullStr |
S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes |
title_full_unstemmed |
S-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes |
title_sort |
s-nitrosylation of transglutaminase 2 impairs fatty acid-stimulated contraction in hypertensive cardiomyocytes |
publisher |
Nature Publishing Group |
series |
Experimental and Molecular Medicine |
issn |
2092-6413 |
publishDate |
2018-04-01 |
description |
Heart disease: A key enzyme for healthy contraction Enhancing activity of an enzyme that promotes healthy heart contraction could benefit patients at risk of serious heart conditions. Chronic high blood pressure can cause excessive thickening of heart muscle tissue, reducing the heart’s ability to contract correctly and leading to heart failure. A healthy heart fuels itself by oxidizing fatty acids to trigger production of the key energy transfer molecule ATP. Yin Hua Zhang and In-Gyu Kim at Seoul National University College of Medicine, Korea and co-workers have highlighted how S-nitrosylation, addition of nitric oxide, affects transglutaminase 2 (TG2), an enzyme that promotes ATP production. Experiments on rats and mice showed that fatty acids activate TG2, increasing ATP production and maintaining contractibility in healthy hearts. However, in pressure-overloaded hearts, TG2 activity is inhibited by S-nitrosylation, which stops heart muscle cells contracting properly. |
url |
https://doi.org/10.1038/s12276-017-0021-x |
work_keys_str_mv |
AT euimanjeong snitrosylationoftransglutaminase2impairsfattyacidstimulatedcontractioninhypertensivecardiomyocytes AT chunzijin snitrosylationoftransglutaminase2impairsfattyacidstimulatedcontractioninhypertensivecardiomyocytes AT jihyunjang snitrosylationoftransglutaminase2impairsfattyacidstimulatedcontractioninhypertensivecardiomyocytes AT zaihaozhao snitrosylationoftransglutaminase2impairsfattyacidstimulatedcontractioninhypertensivecardiomyocytes AT chunlijin snitrosylationoftransglutaminase2impairsfattyacidstimulatedcontractioninhypertensivecardiomyocytes AT jinhanglee snitrosylationoftransglutaminase2impairsfattyacidstimulatedcontractioninhypertensivecardiomyocytes AT kibaeklee snitrosylationoftransglutaminase2impairsfattyacidstimulatedcontractioninhypertensivecardiomyocytes AT sungjoonkim snitrosylationoftransglutaminase2impairsfattyacidstimulatedcontractioninhypertensivecardiomyocytes AT ingyukim snitrosylationoftransglutaminase2impairsfattyacidstimulatedcontractioninhypertensivecardiomyocytes AT yinhuazhang snitrosylationoftransglutaminase2impairsfattyacidstimulatedcontractioninhypertensivecardiomyocytes |
_version_ |
1724389179787313152 |