Integrated rare variant-based risk gene prioritization in disease case-control sequencing studies.

Rare variants of major effect play an important role in human complex diseases and can be discovered by sequencing-based genome-wide association studies. Here, we introduce an integrated approach that combines the rare variant association test with gene network and phenotype information to identify...

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Bibliographic Details
Main Authors: Jhih-Rong Lin, Quanwei Zhang, Ying Cai, Bernice E Morrow, Zhengdong D Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5760082?pdf=render

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