Paget’s Disease Diagnosed on Cranial and Sacroiliac Involvement in Contrast to Normal Alkaline Phosphatase Levels
Paget’s disease of bone is characterized by a chronic focal bone remodelling disorder, which is usually detected incidentally during routine imagining examinations. Although the measurement of total serum alkaline phosphatase usually provides a general indication of bone turnover in Paget’s disease,...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-08-01
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| Series: | Türk Osteoporoz Dergisi |
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| Online Access: |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/pagets-disease-diagnosed-on-cranial-and-sacroiliac/39875
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| Summary: | Paget’s disease of bone is characterized by a chronic focal bone remodelling disorder, which is usually detected incidentally during routine imagining examinations. Although the measurement of total serum alkaline phosphatase usually provides a general indication of bone turnover in Paget’s disease, about 10-15% of patients present with alkaline phosphatase levels within the normal range. The treatment of symptomatic forms relies on bisphosphonates that are efficient in reducing the bone turnover. Here, I present the case of an 80-year-old man suffering from chronic low back pain, and diagnosed as Paget’s disease, with normal serum alkaline phosphatase and bone-specific alkaline phosphatase levels. |
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| ISSN: | 2147-2653 2147-2653 |