A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay

EDC4 is a core component of processing (P)-bodies that binds the DCP2 decapping enzyme and stimulates mRNA decay. EDC4 also interacts with mammalian MARF1, a recently identified endoribonuclease that promotes oogenesis and contains a number of RNA binding domains, including two RRMs and multiple LOT...

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Bibliographic Details
Main Authors: William R Brothers, Steven Hebert, Claudia L Kleinman, Marc R Fabian
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
mRNA decay
RNA binding protein
mRNA decapping
endonuclease
gene expression
Online Access:https://elifesciences.org/articles/54995

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