Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

ApoE4 is a risk factor for small vessel disease, which can lead to cognitive impairment. Here the authors assess the microvasculature of the corpus callosum using 3-photon microscopy and find that mice expressing the ApoE4 allele are more susceptible than wild-type to white matter injury and cogniti...

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Main Authors:	Kenzo Koizumi, Yorito Hattori, Sung Ji Ahn, Izaskun Buendia, Antonio Ciacciarelli, Ken Uekawa, Gang Wang, Abigail Hiller, Lingzhi Zhao, Henning U. Voss, Steven M. Paul, Chris Schaffer, Laibaik Park, Costantino Iadecola
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06301-2

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spelling	doaj-2ab1466f234d4ba0b18f5463e1f09a162021-05-11T09:48:05ZengNature Publishing GroupNature Communications2041-17232018-09-019111110.1038/s41467-018-06301-2Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive functionKenzo Koizumi0Yorito Hattori1Sung Ji Ahn2Izaskun Buendia3Antonio Ciacciarelli4Ken Uekawa5Gang Wang6Abigail Hiller7Lingzhi Zhao8Henning U. Voss9Steven M. Paul10Chris Schaffer11Laibaik Park12Costantino Iadecola13Feil Family Brain and Mind Research Institute, Weill Cornell MedicineFeil Family Brain and Mind Research Institute, Weill Cornell MedicineFeil Family Brain and Mind Research Institute, Weill Cornell MedicineFeil Family Brain and Mind Research Institute, Weill Cornell MedicineFeil Family Brain and Mind Research Institute, Weill Cornell MedicineFeil Family Brain and Mind Research Institute, Weill Cornell MedicineFeil Family Brain and Mind Research Institute, Weill Cornell MedicineFeil Family Brain and Mind Research Institute, Weill Cornell MedicineFeil Family Brain and Mind Research Institute, Weill Cornell MedicineDepartment of Radiology, Weill Cornell MedicineDepartment of Neurology and Psychiatry, Washington University in St. LouisFeil Family Brain and Mind Research Institute, Weill Cornell MedicineFeil Family Brain and Mind Research Institute, Weill Cornell MedicineFeil Family Brain and Mind Research Institute, Weill Cornell MedicineApoE4 is a risk factor for small vessel disease, which can lead to cognitive impairment. Here the authors assess the microvasculature of the corpus callosum using 3-photon microscopy and find that mice expressing the ApoE4 allele are more susceptible than wild-type to white matter injury and cognitive impairment in a model of hypoperfusion-induced hypoxia.https://doi.org/10.1038/s41467-018-06301-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kenzo Koizumi Yorito Hattori Sung Ji Ahn Izaskun Buendia Antonio Ciacciarelli Ken Uekawa Gang Wang Abigail Hiller Lingzhi Zhao Henning U. Voss Steven M. Paul Chris Schaffer Laibaik Park Costantino Iadecola
spellingShingle	Kenzo Koizumi Yorito Hattori Sung Ji Ahn Izaskun Buendia Antonio Ciacciarelli Ken Uekawa Gang Wang Abigail Hiller Lingzhi Zhao Henning U. Voss Steven M. Paul Chris Schaffer Laibaik Park Costantino Iadecola Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function Nature Communications
author_facet	Kenzo Koizumi Yorito Hattori Sung Ji Ahn Izaskun Buendia Antonio Ciacciarelli Ken Uekawa Gang Wang Abigail Hiller Lingzhi Zhao Henning U. Voss Steven M. Paul Chris Schaffer Laibaik Park Costantino Iadecola
author_sort	Kenzo Koizumi
title	Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
title_short	Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
title_full	Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
title_fullStr	Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
title_full_unstemmed	Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
title_sort	apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-09-01
description	ApoE4 is a risk factor for small vessel disease, which can lead to cognitive impairment. Here the authors assess the microvasculature of the corpus callosum using 3-photon microscopy and find that mice expressing the ApoE4 allele are more susceptible than wild-type to white matter injury and cognitive impairment in a model of hypoperfusion-induced hypoxia.
url	https://doi.org/10.1038/s41467-018-06301-2
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Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

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