Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration
Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of sarcopenia, prolonged hospitalization, and lo...
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doaj-2ab1ab28e7844810827bd438d16be76e2020-11-25T01:14:21ZengMDPI AGCells2073-44092019-02-018218310.3390/cells8020183cells8020183Autophagy as a Therapeutic Target to Enhance Aged Muscle RegenerationDavid E. Lee0Akshay Bareja1David B. Bartlett2James P. White3Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USADuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USADuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USADuke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USASkeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of sarcopenia, prolonged hospitalization, and loss of autonomy. Although several age-sensitive pathways have been identified, further investigation is needed to define targets of cellular dysfunction. Autophagy, a process of cellular catabolism, is emerging as a key regulator of muscle regeneration affecting stem cell, immune cell, and myofiber function. Muscle stem cell senescence is associated with a suppression of autophagy during key phases of the regenerative program. Macrophages, a key immune cell involved in muscle repair, also rely on autophagy to aid in tissue repair. This review will focus on the role of autophagy in various aspects of the regenerative program, including adult skeletal muscle stem cells, monocytes/macrophages, and corresponding age-associated dysfunction. Furthermore, we will highlight rejuvenation strategies that alter autophagy to improve muscle regenerative function.https://www.mdpi.com/2073-4409/8/2/183muscle regenerationagingstem cellimmunemacrophagesenescenceexercisecaloric restriction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David E. Lee Akshay Bareja David B. Bartlett James P. White |
spellingShingle |
David E. Lee Akshay Bareja David B. Bartlett James P. White Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration Cells muscle regeneration aging stem cell immune macrophage senescence exercise caloric restriction |
author_facet |
David E. Lee Akshay Bareja David B. Bartlett James P. White |
author_sort |
David E. Lee |
title |
Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title_short |
Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title_full |
Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title_fullStr |
Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title_full_unstemmed |
Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title_sort |
autophagy as a therapeutic target to enhance aged muscle regeneration |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2019-02-01 |
description |
Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of sarcopenia, prolonged hospitalization, and loss of autonomy. Although several age-sensitive pathways have been identified, further investigation is needed to define targets of cellular dysfunction. Autophagy, a process of cellular catabolism, is emerging as a key regulator of muscle regeneration affecting stem cell, immune cell, and myofiber function. Muscle stem cell senescence is associated with a suppression of autophagy during key phases of the regenerative program. Macrophages, a key immune cell involved in muscle repair, also rely on autophagy to aid in tissue repair. This review will focus on the role of autophagy in various aspects of the regenerative program, including adult skeletal muscle stem cells, monocytes/macrophages, and corresponding age-associated dysfunction. Furthermore, we will highlight rejuvenation strategies that alter autophagy to improve muscle regenerative function. |
topic |
muscle regeneration aging stem cell immune macrophage senescence exercise caloric restriction |
url |
https://www.mdpi.com/2073-4409/8/2/183 |
work_keys_str_mv |
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