Using chitosan and xanthan gum mixtures as excipients in controlled release formulations of ambroxol HCl - in vitro drug release and swelling behavior

Directly compressed matrices were produced using a binary mixture of different chitosan (CH) and xanthan gum (XG) ratios. These hydrophilic excipients were used to control the release of ambroxol HCl. CH and XG were investigated at three ratios of 1:1, 1:4 and 4:1. Mucosolvan LA® was used as a comme...

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Main Authors:	Faisal Al-Akayleh, Mayyas Al Remawi, Mutaz S. Salemc, Adnan Badwan
Format:	Article
Language:	English
Published:	International Pharmaceutical Excipients Council
Series:	Journal of Excipients and Food Chemicals
Online Access:	http://jefc.scholasticahq.com/article/951-using-chitosan-and-xanthan-gum-mixtures-as-excipients-in-controlled-release-formulations-of-ambroxol-hcl-in-vitro-drug-release-and-swelling-behavior.pdf

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spelling	doaj-2ab1e9d9c42e4be1a68a0ddbfb0b9d652020-11-24T21:33:18ZengInternational Pharmaceutical Excipients CouncilJournal of Excipients and Food Chemicals2150-2668Using chitosan and xanthan gum mixtures as excipients in controlled release formulations of ambroxol HCl - in vitro drug release and swelling behaviorFaisal Al-AkaylehMayyas Al RemawiMutaz S. SalemcAdnan BadwanDirectly compressed matrices were produced using a binary mixture of different chitosan (CH) and xanthan gum (XG) ratios. These hydrophilic excipients were used to control the release of ambroxol HCl. CH and XG were investigated at three ratios of 1:1, 1:4 and 4:1. Mucosolvan LA® was used as a commercially available reference product. The optimal CH to XG ratio was 1:1 and the optimal drug to polymer ratio was 1:3. Matrix erosion, hydration and drug release studies were carried out using a dissolution apparatus (basket method). The release mechanism is also discussed.http://jefc.scholasticahq.com/article/951-using-chitosan-and-xanthan-gum-mixtures-as-excipients-in-controlled-release-formulations-of-ambroxol-hcl-in-vitro-drug-release-and-swelling-behavior.pdf
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Faisal Al-Akayleh Mayyas Al Remawi Mutaz S. Salemc Adnan Badwan
spellingShingle	Faisal Al-Akayleh Mayyas Al Remawi Mutaz S. Salemc Adnan Badwan Using chitosan and xanthan gum mixtures as excipients in controlled release formulations of ambroxol HCl - in vitro drug release and swelling behavior Journal of Excipients and Food Chemicals
author_facet	Faisal Al-Akayleh Mayyas Al Remawi Mutaz S. Salemc Adnan Badwan
author_sort	Faisal Al-Akayleh
title	Using chitosan and xanthan gum mixtures as excipients in controlled release formulations of ambroxol HCl - in vitro drug release and swelling behavior
title_short	Using chitosan and xanthan gum mixtures as excipients in controlled release formulations of ambroxol HCl - in vitro drug release and swelling behavior
title_full	Using chitosan and xanthan gum mixtures as excipients in controlled release formulations of ambroxol HCl - in vitro drug release and swelling behavior
title_fullStr	Using chitosan and xanthan gum mixtures as excipients in controlled release formulations of ambroxol HCl - in vitro drug release and swelling behavior
title_full_unstemmed	Using chitosan and xanthan gum mixtures as excipients in controlled release formulations of ambroxol HCl - in vitro drug release and swelling behavior
title_sort	using chitosan and xanthan gum mixtures as excipients in controlled release formulations of ambroxol hcl - in vitro drug release and swelling behavior
publisher	International Pharmaceutical Excipients Council
series	Journal of Excipients and Food Chemicals
issn	2150-2668
description	Directly compressed matrices were produced using a binary mixture of different chitosan (CH) and xanthan gum (XG) ratios. These hydrophilic excipients were used to control the release of ambroxol HCl. CH and XG were investigated at three ratios of 1:1, 1:4 and 4:1. Mucosolvan LA® was used as a commercially available reference product. The optimal CH to XG ratio was 1:1 and the optimal drug to polymer ratio was 1:3. Matrix erosion, hydration and drug release studies were carried out using a dissolution apparatus (basket method). The release mechanism is also discussed.
url	http://jefc.scholasticahq.com/article/951-using-chitosan-and-xanthan-gum-mixtures-as-excipients-in-controlled-release-formulations-of-ambroxol-hcl-in-vitro-drug-release-and-swelling-behavior.pdf
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Using chitosan and xanthan gum mixtures as excipients in controlled release formulations of ambroxol HCl - in vitro drug release and swelling behavior

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