The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)

Abstract Purpose Inversion of chromosome 9 (inv[9]) is considered to be a normal variant, and the inv(9) in patients or husbands with recurrent pregnancy loss (RPL) is believed to be harmless. However, there are few reports concerning the outcomes of pregnancy in patients with RPL when the patient o...

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Main Authors: Taro Nonaka, Makiko Takahashi, Chika Nonaka, Takayuki Enomoto, Koichi Takakuwa
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Reproductive Medicine and Biology
Subjects:
Online Access:https://doi.org/10.1002/rmb2.12281
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spelling doaj-2ab62f8f49ea48439eb2c7579218dd422020-11-25T01:09:26ZengWileyReproductive Medicine and Biology1445-57811447-05782019-07-0118329630110.1002/rmb2.12281The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)Taro Nonaka0Makiko Takahashi1Chika Nonaka2Takayuki Enomoto3Koichi Takakuwa4Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata JapanDepartment of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata JapanDepartment of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata JapanDepartment of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata JapanCenter for Perinatal, Maternal and Neonatal Medicine Niigata University Medical and Dental Hospital Niigata JapanAbstract Purpose Inversion of chromosome 9 (inv[9]) is considered to be a normal variant, and the inv(9) in patients or husbands with recurrent pregnancy loss (RPL) is believed to be harmless. However, there are few reports concerning the outcomes of pregnancy in patients with RPL when the patient or their partner has inv(9). In this study, we analyzed the outcomes of pregnancy in this patient population. Methods Chromosomal karyotyping was performed for 2006 couples with RPL (two or more consecutive early pregnancy losses including non‐visualized cases) with their informed consent. The frequency of various chromosomal abnormalities in the patient population was then analyzed, and the outcomes of pregnancy in patients with inv(9) were investigated. Results The frequency of inv(9) in the overall population was 2.6% (52/2006). Thus far, 32 patients have conceived repetitively, resulting in live births in 23 cases and early pregnancy losses in nine cases. Four of the nine cases obtained a good outcome in the subsequent pregnancy. Thus, a successful outcome was obtained in 27 of the 32 (84.4%) cases. Conclusions This study suggests that inv(9) has no adverse influence on subsequent pregnancy.https://doi.org/10.1002/rmb2.12281chromosomal abnormalityinversion of chromosome 9normal variantperinatal prognosisrecurrent pregnancy loss
collection DOAJ
language English
format Article
sources DOAJ
author Taro Nonaka
Makiko Takahashi
Chika Nonaka
Takayuki Enomoto
Koichi Takakuwa
spellingShingle Taro Nonaka
Makiko Takahashi
Chika Nonaka
Takayuki Enomoto
Koichi Takakuwa
The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)
Reproductive Medicine and Biology
chromosomal abnormality
inversion of chromosome 9
normal variant
perinatal prognosis
recurrent pregnancy loss
author_facet Taro Nonaka
Makiko Takahashi
Chika Nonaka
Takayuki Enomoto
Koichi Takakuwa
author_sort Taro Nonaka
title The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)
title_short The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)
title_full The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)
title_fullStr The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)
title_full_unstemmed The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)
title_sort analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)
publisher Wiley
series Reproductive Medicine and Biology
issn 1445-5781
1447-0578
publishDate 2019-07-01
description Abstract Purpose Inversion of chromosome 9 (inv[9]) is considered to be a normal variant, and the inv(9) in patients or husbands with recurrent pregnancy loss (RPL) is believed to be harmless. However, there are few reports concerning the outcomes of pregnancy in patients with RPL when the patient or their partner has inv(9). In this study, we analyzed the outcomes of pregnancy in this patient population. Methods Chromosomal karyotyping was performed for 2006 couples with RPL (two or more consecutive early pregnancy losses including non‐visualized cases) with their informed consent. The frequency of various chromosomal abnormalities in the patient population was then analyzed, and the outcomes of pregnancy in patients with inv(9) were investigated. Results The frequency of inv(9) in the overall population was 2.6% (52/2006). Thus far, 32 patients have conceived repetitively, resulting in live births in 23 cases and early pregnancy losses in nine cases. Four of the nine cases obtained a good outcome in the subsequent pregnancy. Thus, a successful outcome was obtained in 27 of the 32 (84.4%) cases. Conclusions This study suggests that inv(9) has no adverse influence on subsequent pregnancy.
topic chromosomal abnormality
inversion of chromosome 9
normal variant
perinatal prognosis
recurrent pregnancy loss
url https://doi.org/10.1002/rmb2.12281
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