The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)
Abstract Purpose Inversion of chromosome 9 (inv[9]) is considered to be a normal variant, and the inv(9) in patients or husbands with recurrent pregnancy loss (RPL) is believed to be harmless. However, there are few reports concerning the outcomes of pregnancy in patients with RPL when the patient o...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2019-07-01
|
Series: | Reproductive Medicine and Biology |
Subjects: | |
Online Access: | https://doi.org/10.1002/rmb2.12281 |
id |
doaj-2ab62f8f49ea48439eb2c7579218dd42 |
---|---|
record_format |
Article |
spelling |
doaj-2ab62f8f49ea48439eb2c7579218dd422020-11-25T01:09:26ZengWileyReproductive Medicine and Biology1445-57811447-05782019-07-0118329630110.1002/rmb2.12281The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)Taro Nonaka0Makiko Takahashi1Chika Nonaka2Takayuki Enomoto3Koichi Takakuwa4Department of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata JapanDepartment of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata JapanDepartment of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata JapanDepartment of Obstetrics and Gynecology Niigata University Medical and Dental Hospital Niigata JapanCenter for Perinatal, Maternal and Neonatal Medicine Niigata University Medical and Dental Hospital Niigata JapanAbstract Purpose Inversion of chromosome 9 (inv[9]) is considered to be a normal variant, and the inv(9) in patients or husbands with recurrent pregnancy loss (RPL) is believed to be harmless. However, there are few reports concerning the outcomes of pregnancy in patients with RPL when the patient or their partner has inv(9). In this study, we analyzed the outcomes of pregnancy in this patient population. Methods Chromosomal karyotyping was performed for 2006 couples with RPL (two or more consecutive early pregnancy losses including non‐visualized cases) with their informed consent. The frequency of various chromosomal abnormalities in the patient population was then analyzed, and the outcomes of pregnancy in patients with inv(9) were investigated. Results The frequency of inv(9) in the overall population was 2.6% (52/2006). Thus far, 32 patients have conceived repetitively, resulting in live births in 23 cases and early pregnancy losses in nine cases. Four of the nine cases obtained a good outcome in the subsequent pregnancy. Thus, a successful outcome was obtained in 27 of the 32 (84.4%) cases. Conclusions This study suggests that inv(9) has no adverse influence on subsequent pregnancy.https://doi.org/10.1002/rmb2.12281chromosomal abnormalityinversion of chromosome 9normal variantperinatal prognosisrecurrent pregnancy loss |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Taro Nonaka Makiko Takahashi Chika Nonaka Takayuki Enomoto Koichi Takakuwa |
spellingShingle |
Taro Nonaka Makiko Takahashi Chika Nonaka Takayuki Enomoto Koichi Takakuwa The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9) Reproductive Medicine and Biology chromosomal abnormality inversion of chromosome 9 normal variant perinatal prognosis recurrent pregnancy loss |
author_facet |
Taro Nonaka Makiko Takahashi Chika Nonaka Takayuki Enomoto Koichi Takakuwa |
author_sort |
Taro Nonaka |
title |
The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9) |
title_short |
The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9) |
title_full |
The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9) |
title_fullStr |
The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9) |
title_full_unstemmed |
The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9) |
title_sort |
analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9) |
publisher |
Wiley |
series |
Reproductive Medicine and Biology |
issn |
1445-5781 1447-0578 |
publishDate |
2019-07-01 |
description |
Abstract Purpose Inversion of chromosome 9 (inv[9]) is considered to be a normal variant, and the inv(9) in patients or husbands with recurrent pregnancy loss (RPL) is believed to be harmless. However, there are few reports concerning the outcomes of pregnancy in patients with RPL when the patient or their partner has inv(9). In this study, we analyzed the outcomes of pregnancy in this patient population. Methods Chromosomal karyotyping was performed for 2006 couples with RPL (two or more consecutive early pregnancy losses including non‐visualized cases) with their informed consent. The frequency of various chromosomal abnormalities in the patient population was then analyzed, and the outcomes of pregnancy in patients with inv(9) were investigated. Results The frequency of inv(9) in the overall population was 2.6% (52/2006). Thus far, 32 patients have conceived repetitively, resulting in live births in 23 cases and early pregnancy losses in nine cases. Four of the nine cases obtained a good outcome in the subsequent pregnancy. Thus, a successful outcome was obtained in 27 of the 32 (84.4%) cases. Conclusions This study suggests that inv(9) has no adverse influence on subsequent pregnancy. |
topic |
chromosomal abnormality inversion of chromosome 9 normal variant perinatal prognosis recurrent pregnancy loss |
url |
https://doi.org/10.1002/rmb2.12281 |
work_keys_str_mv |
AT tarononaka theanalysisofchromosomalabnormalitiesinpatientswithrecurrentpregnancylossfocusingontheprognosisofpatientswithinversionofchromosome9 AT makikotakahashi theanalysisofchromosomalabnormalitiesinpatientswithrecurrentpregnancylossfocusingontheprognosisofpatientswithinversionofchromosome9 AT chikanonaka theanalysisofchromosomalabnormalitiesinpatientswithrecurrentpregnancylossfocusingontheprognosisofpatientswithinversionofchromosome9 AT takayukienomoto theanalysisofchromosomalabnormalitiesinpatientswithrecurrentpregnancylossfocusingontheprognosisofpatientswithinversionofchromosome9 AT koichitakakuwa theanalysisofchromosomalabnormalitiesinpatientswithrecurrentpregnancylossfocusingontheprognosisofpatientswithinversionofchromosome9 AT tarononaka analysisofchromosomalabnormalitiesinpatientswithrecurrentpregnancylossfocusingontheprognosisofpatientswithinversionofchromosome9 AT makikotakahashi analysisofchromosomalabnormalitiesinpatientswithrecurrentpregnancylossfocusingontheprognosisofpatientswithinversionofchromosome9 AT chikanonaka analysisofchromosomalabnormalitiesinpatientswithrecurrentpregnancylossfocusingontheprognosisofpatientswithinversionofchromosome9 AT takayukienomoto analysisofchromosomalabnormalitiesinpatientswithrecurrentpregnancylossfocusingontheprognosisofpatientswithinversionofchromosome9 AT koichitakakuwa analysisofchromosomalabnormalitiesinpatientswithrecurrentpregnancylossfocusingontheprognosisofpatientswithinversionofchromosome9 |
_version_ |
1725178826977181696 |