The analysis of chromosomal abnormalities in patients with recurrent pregnancy loss, focusing on the prognosis of patients with inversion of chromosome (9)

• Main Authors: Taro Nonaka, Makiko Takahashi, Chika Nonaka, Takayuki Enomoto, Koichi Takakuwa
• Format: Article
• Language: English
• Published: Wiley 2019-07-01
• Series: Reproductive Medicine and Biology
• Subjects: chromosomal abnormality; inversion of chromosome 9; normal variant; perinatal prognosis; recurrent pregnancy loss
• Online Access: https://doi.org/10.1002/rmb2.12281

Abstract Purpose Inversion of chromosome 9 (inv[9]) is considered to be a normal variant, and the inv(9) in patients or husbands with recurrent pregnancy loss (RPL) is believed to be harmless. However, there are few reports concerning the outcomes of pregnancy in patients with RPL when the patient or their partner has inv(9). In this study, we analyzed the outcomes of pregnancy in this patient population. Methods Chromosomal karyotyping was performed for 2006 couples with RPL (two or more consecutive early pregnancy losses including non‐visualized cases) with their informed consent. The frequency of various chromosomal abnormalities in the patient population was then analyzed, and the outcomes of pregnancy in patients with inv(9) were investigated. Results The frequency of inv(9) in the overall population was 2.6% (52/2006). Thus far, 32 patients have conceived repetitively, resulting in live births in 23 cases and early pregnancy losses in nine cases. Four of the nine cases obtained a good outcome in the subsequent pregnancy. Thus, a successful outcome was obtained in 27 of the 32 (84.4%) cases. Conclusions This study suggests that inv(9) has no adverse influence on subsequent pregnancy.